GROWTH AND HEALTH STUDY EXTENSION

NHLBI增长与健康研究(NCHS)的延期，为期七年 肥胖发生发展及其对健康影响的队列研究 2379名黑人和白人青少年的心血管疾病危险因素 女性，建议继续对队列进行跟踪，直到受试者 达到成年早期，这一时期与健康相关的终生模式 行为是建立的。在青春期前的受试者中，没有 在身体成分或血压方面存在显著的种族差异 黑人女孩的低密度脂蛋白和甘油三酯较低，高密度脂蛋白较高。 胆固醇。到了13-14岁，黑人女性的体重明显增加， 皮褶厚度和周长明显大于 白人女性。然而，这些变化并没有伴随而来。 已知与肥胖密切相关的心血管危险因素的变化： 在13-14岁，黑人女孩的高密度脂蛋白-胆固醇仍然较高，而较低 甘油三酯和血压的种族差异不是 始终如一的重要。CARDIA的数据表明，在18-24岁的时候， 黑人女性的血压和低密度脂蛋白-胆固醇明显更高。 这表明与肥胖相关的心血管疾病危险因素将会发生变化。 在青春期晚期-成年期早期。只是一项纵向研究 跨越这一时期可以解释黑人女性心血管疾病风险增加的原因 成年早期观察到的。NGHS III将跟随这群女孩 直到他们达到成年早期(19-20岁)。具体地说，NGHS III检查：L)体重、体脂及脂肪分布的变化；2) 饮食摄入量和体力活动模式的变化；3)变化 血压和血脂；4)空腹血糖和胰岛素水平；5) 心理社会因素(例如，自我概念、压力、应对、饮食 关于身体形象和体重的实践、态度和信念)；6) 吸烟和饮酒的发生；7)怀孕。持续跟进 将为以下方面提供重要的科学信息 通过潜在地确定切实可行的领域来改善妇女的健康 预防肥胖及其相关后遗症的干预措施。

An extension to the NHLBI Growth and Health Study (NCHS), a seven-year cohort study of the development of obesity and its effects on cardiovascular disease risk factors in 2 ,379 black and white adolescent females, is proposed to continue follow-up of the cohort until subjects reach early adulthood, a time when lifelong patterns of health-related behaviors are established. In prepubertal subjects, there were no significant race differences in body composition or blood pressure and black girls had lower LDL-cholesterol and triglycerides and higher HDL- cholesterol. By ages 13-14, black females weighed significantly more and had significantly larger skinfold thicknesses and circumferences than white females. However, these changes were not accompanied by concomitant changes in CVD risk factors known to be strongly associated with obesity: at ages 13-14, black girls still had higher HDL-cholesterol and lower triglycerides and racial differences in blood pressure were not consistently significant. Data from CARDIA indicate that at ages 18-24, black females had significantly higher blood pressure and LDL-cholesterol. This suggests that obesity-related changes in CVD risk factors will occur in the late adolescent-early adulthood period. Only a longitudinal study spanning this period can explain the increased CVD risk in black women observed by early adulthood. NGHS III will follow this cohort of girls until they have reached early adulthood (ages 19-20). Specifically, NGHS III will examine: l) changes in weight, body fat and fat distribution; 2) changes in dietary intakes and physical activity patterns; 3) changes in blood pressure and blood lipids; 4) fasting glucose and insulin levels; 5) psychosocial factors (e.g., self-concept, stress, coping, dietary practices and attitudes and beliefs about body image and weight); 6) occurrence of smoking and alcohol use; 7) pregnancy. Continued follow-up of the NGHS cohort will yield important scientific information for improving women's health by potentially identify areas for practical interventions to prevent obesity and its related sequelae.