Analysis of Sex Hormones and Lipoproteins in Young Males

描述 （申请人提供）本申请请求支持中学 青春期男性性激素及脂蛋白水平分析 (HD/HL 18281），一项为期3年（1984-1987）的血脂、血压、体重 脂肪模式，和性类固醇激素（SSH）在青春期男性。 共 的664名黑人和白色男性，年龄在10-15岁，被纳入一项研究， 作为一系列重复的数据收集超过2年内的年龄组。 横截面分析已被用来解释差异， 青春期黑人和白色男孩之间SSH和SSH-脂质关系 在有和没有CHD家族史的男孩之间。 当数据被 本研究最初收集的，灵活的理论模型 纵向分析技术已经开发出来，但还没有 用于计算机使用。 这些技术现在得到了软件的支持， 强大而完整的分析这些数据。 这些分析的主要目的是阐明变化的贡献 在SSH和脂肪模式的变化，血浆浓度高（HDL-C） 和低（LDL-C）密度脂蛋白胆固醇、甘油三酯（TG）， 男性青春期出现的载脂蛋白（apo）Al、All和B。 SSH 测定包括雌二醇（E2）和游离睾酮（T）。 我们将测试 以下假设：（1）增加游离T预测/导致 青少年HDL-C和LDL-C、apo B和LDL-C/HDL-C比值升高 男性;（2）E2升高预示载脂蛋白B、LDL-C和LDL-C/HDL降低。 C比例，但由此产生的影响将因肥胖和脂肪 图案化;（3）快速体重增加预示着增加的中枢性肥胖， 定义为躯干皮褶与总皮褶的比率， HDL-C降低，甘油三酯、载脂蛋白B、LDL-C和LDL- C/HDL-C比值。 快速体重增加预示E2增加，但动脉粥样硬化 中心性肥胖增加对血脂的影响大于抗肥胖。 E2的致动脉粥样硬化作用。 这些分析将提供对代谢因素的更好理解 潜在的肥胖-激素-脂蛋白关系。 因为井- 在美国青年肥胖症的增加记录，这些分析是 特别是针对重要的公共卫生问题。

DESCRIPTION (Provided by Applicant) This application requests support for secondary analysis of the Sex Hormones and Lipoproteins in Adolescent Males Study (HD/HL18281), a 3-year (1984-1987) study of lipids, blood pressure, weight, fat patterning, and sex steroid hormones (SSH) in adolescent males. A total of 664 black and white males, ages 10-15, were enrolled into a study designed as a series of repeated data collections over 2 years within age cohorts. Cross-sectional analyses have been used to explain differences during adolescence in SSH and SSH-lipid relationships between black and white boys and between boys with and without a family history of CHD. When the data were originally collected for this study, theoretical models of flexible longitudinal analytic techniques had been developed, but were not available for computer use. These techniques, now supported by software, allow a more powerful and complete analysis of these data. The primary aim of these analyses is to explicate the contribution of changes in SSH and fat patterning to changes in plasma concentrations of high (HDL-C) and low (LDL-C) density lipoprotein cholesterol, triglycerides (TG), and apolipoproteins (apo) Al, All, and B occurring during puberty in males. SSH assayed included estradiol (E2) and free testosterone (T). We will test the following hypotheses: (1) increasing free T predicts/leads to decreases in HDL-C and increases in LDL-C, apo B, and the LDL-C/HDL-C ratio in adolescent males; (2) increasing E2 predicts decreases in apo B, LDL-C and the LDL-C/HDL- C ratio, but the resultant effects will vary with adiposity and fat patterning; (3) rapid weight gain predicts increased central adiposity, defined as the ratio of truncal skinfolds to total skinfolds, and with greater decreases in HDL-C and increases in triglycerides, apo B, LDL-C and the LDL- C/HDL-C ratio. Rapid weight gain predicts increased E2, but the atherogenic effects of increased central adiposity on lipids are greater than the anti- atherogenic effects of E2. These analyses will provide a better understanding of metabolic factors underlying obesity-hormone-lipoprotein relationships. Given the well- documented increase in obesity in American youth, these analyses are especially pertinent and address important public health issues.