FRACTAL DIMENSION FEATURES FOR MRI BREAST MASS ANALYSIS

用于 MRI 乳腺肿块分析的分形维度特征

• 批准号: 2012579
• 负责人: ALAN I. PENN
• 金额: $ 10万
• 依托单位: ALAN PENN AND ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-09 至 1999-03-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2012579
• 关键词: breast neoplasm /cancer diagnosis; breast neoplasms; computer assisted diagnosis; computer system design /evaluation; diagnosis design /evaluation; female; human data; magnetic resonance imaging; mathematical model; mathematics; method development; model design /development

We propose developing a robust algorithm to evaluate the fractal dimension (fd) of borders of Magnetic Resonance (MR) images of breast masses which contain a small number of pixels. The fd algorithm will be evaluated in upcoming MR breast clinical trials and will be marketed to developers of computer-aided diagnosis systems for MR breast imaging. Contrast-enhanced MR is a promising tool for detecting and diagnosing masses in dense, radio-opaque and scarred breasts. Since border roughness is correlated to breast cancer and fd is a measure of roughness, the proposed algorithm will generate an objective indicator of malignancy. Current algorithms for estimating fd which use box counting or fractional Brownian motion are non-robust when applied to images with limited pixel data. The proposed algorithm generates a family of fractal interpolation function models and derives robust fd estimates from she statistics of the models. The proposed algorithm computes the following features: (a) an estimate of fd of the mass border, (b) a measure of the reliability of the estimate, (c) a measure of the extent of self-affinity of the border, and (d) a measure of the stability of the estimate over a range of threshold levels. PROPOSED COMMERCIAL APPLICATION: A computer-aided diagnosis system which reliably discriminates benign from malignant masses will have a significant market value to MR! centers and developers who have an interest in developing and promoting MR! as an adjunctive method of screening for breast cancer. Since our product enhances the performance of such a system, there is a large commercial potential and a readily identified pool of prospective strategic partners.

我们建议开发一种鲁棒算法来评估分形