Computer-aided decision model for interpreting breast MR

描述(由申请人提供)：这个项目的总体目标是开发、评估和商业化计算机辅助诊断(CAD)系统，该系统支持用于解释乳房磁共振图像的增强决策模型。拟议的系统将使临床医生能够更容易地将乳房磁共振纳入他们的决策和患者护理中。其具体目的是开发一种综合方法学，将在乳腺MR方面具有最少临床经验的放射科医生的敏感率提高到与具有丰富乳房MR经验的放射科医师的敏感率接近的水平。综合方法学包括三个组成部分：1)增强Nunes、Schanll等人先前提出的解释模型。以包含基于病变密度和动力学的其他决策节点。2)为读者提供一个CAD系统，该系统显示定量和可视化的辅助工具，以帮助在决策节点进行解释。3)编写培训工具和案例研究，教放射科医生如何解释和识别病变特征。该CAD系统是基于前人研究开发的表面统计分维特征和边界统计分维特征而开发的。CAD系统将使用一个机构联盟的MR图像数据进行开发和测试，这些机构使用不同的协议和MR系统。一项读者研究将评估具有最少临床经验的放射科医生在接受CAD支持时解释和诊断乳腺MR的能力的变化。

DESCRIPTION (provided by applicant): The overall goal of this project is to develop, evaluate and commercialize a computer-aided-diagnosis (CAD) system that supports an enhanced decision model for interpreting breast MR images. The proposed system will enable clinicians to more readily incorporate breast MR into their decision-making and patient care. The specific aim is to develop an integrated methodology to improve sensitivity rates of radiologists with minimal clinical experience in breast MR to levels that approximate sensitivity rates of radiologists with extensive experience in breast MR. The integrated methodology has three components: 1) Enhance the interpretation model previously proposed by Nunes, Schanll, et al. to contain additional decision nodes based on lesion density and kinetics. 2) Provide readers with a CAD system that displays quantitative and visualization aids to assist in the interpretation at the decision nodes. 3) Generate training tools and case studies for teaching radiologists how to interpret and identify lesion characteristics. The CAD system is based on the statistical surface fractal features and statistical border fractal features developed in prior research. The CAD system will be developed and tested using MR image data from a consortium of institutions that use different protocols and MR systems. A reader study will evaluate changes in interpretive and diagnostic performance of radiologists who have minimal clinical experience interpreting breast MR when they are provided with CAD support.