INHIBITION OF HIV1 NEF-SH3 INTERACTIONS

抑制 HIV1 NEF-SH3 相互作用

• 批准号: 2421642
• 负责人: ADRIANA HEGUY
• 金额: $ 10万
• 依托单位: OSI PHARMACEUTICALS, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2421642
• 关键词: Fungi; antiAIDS agent; biological products; drug design /synthesis /production; human immunodeficiency virus 1; protein kinase; virus protein

DESCRIPTION: (Adapted from Applicant's Abstract) Nef is a key protein involved in the pathway of HIV infectivity. Nef binds to the SH3 domain of the Src family of kinases, although its role in infectivity is still unclear. Using a newly developed assay for Nef-SH3 binding the investigators will use high-throughput screening of 40,000 fungal extracts for binding to the Nef-SH3 complex. After confirmation of activity, active extracts will be selected for initial purification and characterization of active principles.

描述：（改编自申请人的摘要）Nef是一种关键蛋白质 参与了艾滋病病毒的传染途径。Nef与SH 3结构域结合 Src家族激酶，尽管它在感染性中的作用仍然是 不清楚使用新开发的Nef-SH 3结合试验， 研究人员将对40，000种真菌进行高通量筛选 用于结合Nef-SH 3复合物的提取物。确认后 活性，将选择活性提取物进行初始纯化， 活性成分的表征。