MACRONUTRIENTS AND BLOOD PRESSURE HAWAII INTERMAP CENTER

大量营养素和血压夏威夷 INTERMAP 中心

• 批准号: 2519521
• 负责人: BEATRIZ L. RODRIGUEZ
• 金额: $ 6.71万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-22 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2519521
• 关键词: Hawaii; Hawaiian; age difference; alcoholic beverage consumption; antioxidants; caffeine; calcium; cardiovascular disorder epidemiology; dietary constituent; gender difference; human subject; hypertension; magnesium; nutrition related tag; questionnaires; racial /ethnic difference; salt intake; urinalysis

DESCRIPTION: (Adapted from Investigator's Abstract) INTERMAP is a basic epidemiologic investigation designed to help clarify unanswered questions on the role of dietary factors, particularly macronutrients, in the etiology of unfavorable blood pressure (BP) levels prevailing for a majority of middle-aged and older individuals in the United States. A particular focus is to help elucidate the role of these dietary factors in accounting for the even more adverse BP patterns of less educated population strata, e.g., in the U.S. in both less educated blacks and whites. INTERMAP's design is patterned after the tested INTERSALT model: large sample size of 5,200 persons (2,600 men and 2,600 women) ages 40-59 from 20 population samples of varied ethnicity, SES and dietary habits in 4 countries (China, Japan, U.K. and the U.S.; 260 persons per sample). The investigators' group is to provide one (1) of the 8 diverse U.S. INTERMAP samples. Specific aims involve elucidating influences on BP of amount and type of protein, lipids, carbohydrates, and also amino acids, Ca, Mg, antioxidants, fiber, and caffeine. Primary hypotheses to be tested, with control for BMI, intake of alcohol, age, sex, and other confounders are as follow: dietary protein is inversely related to BP; inverse relations between education and BP are significantly accounted for by education-related differences in dietary protein intake; there is a direct relation to BP of dietary SFA, cholesterol, Keys score, starch; there is an inverse relation of PFA and P/S. Participants, randomly selected, are to provide one timed 24-hr. urine collection for assessment of Na, K, creatine, and urea, and they are to complete four 24-hr. dietary recalls. BP is to be measured twice at each of four clinic visits, with standardization and strict quality control of all procedures. The study is to be coordinated by two Coordinating Centers--Northwestern University, Chicago and London School of Hygiene & Tropical Medicine. Urinary determinations are to be made at a Central Laboratory in Leuven, Belgium. Twenty-four hour dietary recalls are to be converted into nutrients with use of the Nutrition Data System of the University of Minnesota's Nutrition Coordinating Center. Data analyses to test hypotheses are to be done at the London Coordinating Center. Overall study findings are to be used to estimate favorable impact on BP of multiple improvements in nutrition by populations. The investigators state that this should aid in making additional dietary recommendations toward the goal of primary prevention of hypertension and shifting BP distributions downward to avoid excess risk associated with present levels generally above optimal.

描述：（改编自研究者的摘要）INTERMAP 是一个基本的 流行病学调查旨在帮助澄清悬而未决的问题 饮食因素，特别是宏量营养素，在 不良血压（BP）水平普遍存在的病因学 美国的大多数中年人和老年人。一个 特别关注的是帮助阐明这些饮食因素的作用 解释了受教育程度较低的人的更不利的血压模式 人口阶层，例如在美国，受教育程度较低的黑人和 白人。 INTERMAP 的设计是根据经过测试的 INTERSALT 模型进行设计的： 大样本规模，5,200 人（2,600 名男性和 2,600 名女性），年龄 40-59 岁 来自不同种族、社会经济地位和饮食习惯的 20 个人口样本 4 个国家（中国、日本、英国和美国；每个国家 260 人） 样本）。研究人员小组将提供 8 项中的一 (1) 项 不同的美国 INTERMAP 样本。具体目标包括阐明 蛋白质、脂质、碳水化合物的数量和类型对血压的影响 还有氨基酸、钙、镁、抗氧化剂、纤维和咖啡因。 待检验的主要假设，控制 BMI、摄入量 酒精、年龄、性别和其他混杂因素如下：膳食蛋白质 与 BP 成反比；教育程度与 BP 呈反比关系 与教育相关的差异在很大程度上造成了 膳食蛋白质摄入量；膳食 SFA 与血压有直接关系， 胆固醇、Keys 评分、淀粉； PFA 和之间存在反比关系 P/S。随机选择的参与者将提供 24 小时一次的时间。 收集尿液以评估 Na、K、肌酸和尿素，并且它们 是要完成四个24小时。饮食回忆。血压要测量两次 每四次就诊，均采用标准化和严格的质量 控制所有程序。该研究将由两个机构协调 协调中心--西北大学、芝加哥大学和伦敦学院 卫生与热带医学。需进行尿液测定 在比利时鲁汶的一个中心实验室。二十四小时饮食 召回将利用营养数据转化为营养素 明尼苏达大学营养协调中心系统。 检验假设的数据分析将在伦敦进行 协调中心。总体研究结果将用于估计 营养的多重改善对血压产生有利影响 人口。调查人员表示，这应该有助于 实现初级预防目标的额外饮食建议 高血压并将血压分布向下移动以避免血压过高 与目前水平通常高于最佳水平相关的风险。