SEARCH for Diabetes in Youth 2: Hawaii Center

搜索青少年糖尿病 2：夏威夷中心

• 批准号: 7086543
• 负责人: BEATRIZ L. RODRIGUEZ
• 金额: $ 62.51万
• 依托单位: PACIFIC HEALTH RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7086543
• 关键词: SEARCH; Diabetes; Youth; Hawaii; Center

DESCRIPTION (provided by applicant): The proposal builds upon a five year research project, SEARCH for Diabetes in Youth, and its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical sites, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006-2008) incident cases age less than 20 years in order to estimate temporal trends in incidence of diabetes mellitus (DM) in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed DM according to clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; and AIM 4: Develop and validate simple and low-cost case definitions and classifications of DM types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood DM research; an epidemiologic study, unique in the United States, of temporal trends in the incidence of DM in youth; a pathophysiologic component addressing the natural history of DM in youth; a study of processes of care and quality of life; and a public health perspective on case classification of DM in youth. This research is critically important to public health as it will provide information about whether and how much DM is increasing among youth of different racial/ethnic groups in the U.S., how DM impacts physical health, including complications, as well as valuable data regarding the quality of care and quality of life of these youth. The SEARCH study in Hawaii is population-based, with the three health insurance plans participating in the study including in their membership nearly 80% of the population of the State. Approximately 80% of the youth enrolled in SEARCH in Hawaii belong to an ethnic minority group, primarily Asian/Pacific Islanders (API). The Hawaii Center had the highest response rate to in person visits in the study and accounts for approximately half of the API cases included in the study nationwide. SEARCH data indicates that the prevalence of Type 2 diabetes among API was 3 times higher compared to non-Hispanic whites. As a study center, Hawaii offers many advantages including a low rate of uninsured residents and low migration, and due to geographic isolation, diabetes care is received almost exclusively within the State.

描述（由申请人提供）：该提案建立在一个为期五年的研究项目，青年糖尿病及其标准化数据收集工作，经验丰富的研究团队，建立病例确定基础设施和种族多样化的人口基础之上。 这是一个来自六个临床研究中心的共同的综合申请，它建议继续和扩大由临床研究中心进行的工作，以解决以下具体的研究目标：目的1：（2006-2008年）年龄小于20岁的发病病例，以估计青年糖尿病（DM）发病率的时间趋势;目的2：对2002-2005年招募到糖尿病研究中心的事件病例进行纵向随访，以根据临床和生化因素记录新诊断的糖尿病的演变;目的3：完成了在护理质量评估的前五年启动的分析，并扩大了护理质量评估的范围，以涵盖更广泛定义的概念和措施，质量;目标4：制定和验证简单和低成本的病例定义和青年糖尿病类型的分类，可用于公共卫生监测。 这项建议的新奇包括其综合性，汇集了主要和及时方面的儿童糖尿病研究;流行病学研究，在美国独特的，在青年糖尿病发病率的时间趋势;一个病理生理成分，解决糖尿病的自然历史在青年;护理过程和生活质量的研究;和公共卫生的角度来看，在青年糖尿病病例分类。 这项研究对公共卫生至关重要，因为它将提供有关美国不同种族/民族青年中DM是否增加以及增加多少的信息，DM如何影响身体健康，包括并发症，以及有关这些青年的护理质量和生活质量的宝贵数据。 夏威夷的健康保险研究是以人口为基础的，参与研究的三个健康保险计划的成员包括该州近80%的人口。 在夏威夷，大约80%的青年属于少数民族群体，主要是亚洲/太平洋岛民（API）。 夏威夷中心在研究中对亲自访问的响应率最高，约占全国研究中包括的API病例的一半。 研究数据表明，与非西班牙裔白人相比，API中2型糖尿病的患病率高3倍。 作为一个研究中心，夏威夷提供了许多优势，包括低比例的无保险居民和低移民，并由于地理隔离，糖尿病护理几乎完全是在国家。