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AEROBIC EXERCISE IN CYSTIC FIBROSIS

囊性纤维化的有氧运动

基本信息

批准号：
2415626
负责人：
DAVID M ORENSTEIN
金额：
$ 19.25万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-05-01 至 1999-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2415626
关键词：
adolescence (12-20) behavioral /social science research tag behavioral medicine cystic fibrosis exercise gender difference health service demonstration project home health care human mortality human subject human therapy evaluation monitoring device physical fitness quality of life rehabilitation respiratory function therapy compliance

项目摘要

Cystic fibrosis (CF) is the most common inherited life-shortening disease among white populations, and is characterized by progressive loss of pulmonary function, exercise tolerance, and quality of life. Previous short-term studies have shown that patients with CF may benefit from aerobic exercise, with improved cardiopulmonary fitness, exercise tolerance, and perhaps either improvement or delay in the expected deterioration in lung function. Recent observations have confirmed a strong correlation between aerobic fitness and survival in patients with CF There have been no published studies that used behavioral medicine techniques to secure compliance with a long-term aerobic exercise program for patients with CF, aged 8 - 18 years, to see if the benefits, particularly the increase in aerobic fitness, seen with short programs could be sustained. This proposal would institute a controlled randomized study of one year of at-home aerobic exercise (stair-stepping) compared with at-home upper body weight-lifting exercise (that is unlikely to increase aerobic fitness) for patients with CF. The study design incorporates state-of-the-art behavioral medicine techniques and a strong money-based incentive system to secure patients' continued participation. The effects of such a program on aerobic fitness (measured as peak oxygen consumption), exercise tolerance, pulmonary function, upper body strength, and quality of life will be measured. This intervention has the potential to increase CF patients' fitness, pulmonary function, life-quality, and even longevity.

囊性纤维化是最常见的遗传性缩短寿命的疾病。在白人人群中，其特点是逐渐丧失肺功能、运动耐量和生活质量。上一首短期研究表明，慢性阻塞性肺疾病患者可能受益于有氧运动，改善心肺健康，锻炼容忍度，也许是预期的改善或延迟肺功能恶化。最近的观察证实了一个有氧健身与慢性阻塞性肺疾病患者生存的强相关性 Cf目前还没有发表过使用行为医学的研究确保遵守长期有氧运动计划的技巧对于8-18岁的CF患者，看看是否有好处，特别是有氧健身的增加，可以从短节目中看到可能会持续下去。这项提议将建立一个受控的随机一年家庭有氧运动(踏步)的对比研究在家中进行上半身举重练习(这不太可能增加有氧健身)为慢性纤维性心脏病患者。研究设计结合了最先进的行为医学技术和强大的以金钱为基础的激励制度，以确保患者的持续参与。这样的计划对有氧体能(以最高氧量衡量)的影响消耗)，运动耐量，肺功能，上身力量，生活质量将被衡量。这种干预有可能提高CF患者的身体素质、肺功能、生活质量和甚至是长寿。