BELIEFS AND ATTITUDES TOWARDS HEREDITARY PROSTATE CANCER

对遗传性前列腺癌的信念和态度

• 批准号: 2660687
• 负责人: NEDAL H. ARAR
• 金额: $ 2.62万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-11-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2660687
• 关键词: attitude; behavioral /social science research tag; belief; data collection methodology /evaluation; family genetics; genetic counseling; genetic disorder diagnosis; health surveys; human subject; interview; male; neoplasm /cancer genetics; prostate neoplasms; public opinion; questionnaires; statistics /biometry

Knowing the mutations of disease genes, researchers can develop genetic tests that are helpful for a variety of clinical purposes, such as screening, prenatal diagnosis, and genetic counseling. As the research on the genetic background of Huntington disease, colon cancer, and breast cancer shows, studies are needed that investigate what affected individuals and their relatives know and understand about a genetic disease, how they perceive their genetic risks and think about genetic testing. These studies can provide valuable information for (1) the improvement of relationships between physicians and patients, (2) genetic counseling, and (3) the development of disease prevention programs. Prostate cancer is the second most common cause of cancer death in American men. Recently, a region on chromosome 1 was identified for potential gene(s) in a family study. It is anticipated that this gene will soon be identified, and a genetic test will be developed. Not much is known about the general population's view on prostate cancer as a genetic disease. Therefore this study will investigate the opinions of individuals from prostate cancer families ascertained in an ongoing prostate cancer family study, conducted since 1996 in San Antonio, Texas. Fifteen prostate cancer patients and 30 (healthy) first degree relatives will be interviewed to investigate their beliefs, attitude, and perceptions towards prostate cancer genetic risk, and genetic testing. The application of clinically applied medical anthropology for the designing of an interview with open-ended question will provide the investigator with the necessary flexibility to explore a wide range of participants' opinions. Interviews will be analyzed using qualitative methods. Variables obtained from this "qualitative analysis" will be analyzed with statistical methods in an exploratory way.

了解疾病基因的突变，研究人员可以开发遗传 有助于各种临床目的的测试，例如 筛查、产前诊断和遗传咨询。作为研究， 亨廷顿病、结肠癌和乳腺癌的遗传背景 癌症显示，需要研究是什么影响了 个人及其亲属知道并了解遗传 疾病，他们如何看待他们的遗传风险， 试验.这些研究可以为以下方面提供有价值的信息：（1） 改善医患关系，（2）遗传 咨询;（3）制定疾病预防计划。 前列腺癌是癌症死亡的第二大常见原因， 美国男人最近，1号染色体上的一个区域被确定为 潜在的基因（S）在家庭研究。预计该基因将 不久将被识别，并将开发一种基因测试。之甚少 了解一般人群对前列腺癌的看法， 疾病因此，本研究将调查个人的意见 来自正在进行的前列腺癌中确定的前列腺癌家族 家庭研究，自1996年以来在德克萨斯州的圣安东尼奥进行。十五前列腺 癌症患者和30名（健康）一级亲属将被 访谈调查他们的信念、态度和看法 前列腺癌的遗传风险和基因检测。应用 临床应用医学人类学的设计， 开放式问题访谈将为研究者提供 这是一个必要的灵活性，以探讨广泛的参与者的意见。 访谈将使用定性方法进行分析。获得的变量 从这一“定性分析”将分析与统计方法 以探索的方式。