Antimicrobial paint-on bandages for Digital Dermatitis

用于数字皮炎的抗菌涂抹绷带

• 批准号: 74008
• 金额: $ 27.61万
• 依托单位: NOBACZ HEALTHCARE LIMITED
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=74008
• 关键词: Antimicrobial; paint; bandages; Digital; Dermatitis

Bandages have two primary roles: firstly, they cover a wound to stop it getting dirty and infected and secondly they allow any ointments or other applied treatments to be 'locked in', so that they don't get rubbed off and can have their effect where needed. However, bandages do not do well in the wet- such as the bath, the shower or just outside in the rain. They generally should not touch the wound directly but, instead, a sterile dressing is used and all of this is time consuming to take off and replace, on a regular basis, as the wound heals. Our company, NoBACZ Healthcare Ltd, has developed liquids that can be painted or squeezed directly onto wounds where they rapidly set, forming robust barriers that naturally degrade and shed over time and can be re-applied as required. These paint-on bandages do very well in the wet as they repel water, do not need an under dressing and are designed to repel bacteria. They could be used for any trauma wounds or surgical wounds in humans or animals, but we have identified a particularly unmet need in a disease of dairy cattle, called 'digital dermatitis'. Here, cattle get painful ulcers on their feet, which are infected with slurry-dwelling bacteria, and these are terribly hard to treat. The cost to the farming industry in the UK alone is about £60 million per annum. Worldwide it is well over a billion pounds per annum. In a small study at the University of Cambridge farm, we showed that these liquid bandages adhere well to digital dermatitis wounds, have no obvious adverse effects, promote healing and overcome associated lameness one week after a single application. We now plan to show in a large farm trial that there is a convincing case on the grounds of treatment effectiveness, animal welfare and economics for the adoption of our liquid bandages by the dairy farming community, worldwide, for the management of digital dermatitis.

绷带有两个主要作用：首先，它们覆盖在伤口上，防止伤口变脏和感染；其次，它们可以“锁住”任何药膏或其他应用的治疗方法，这样它们就不会被擦掉，可以在需要的地方发挥作用。然而，绷带在潮湿的环境中效果不佳，比如洗澡、淋浴或在室外淋雨。他们通常不应该直接接触伤口，而是使用无菌敷料，随着伤口愈合，所有这些都是费时的，需要定期取下和更换。NoBACZ医疗保健有限公司开发了一种液体，可以直接涂在伤口上或挤压在伤口迅速凝固的地方，形成坚固的屏障，随着时间的推移自然降解和脱落，可以根据需要重新应用。这些涂漆的绷带在潮湿的情况下效果很好，因为它们可以防水，不需要包扎，而且可以抵御细菌。它们可以用于人类或动物的任何创伤伤口或手术伤口，但我们已经确定了一种特别未满足的需求，即奶牛的疾病，称为“数字性皮炎”。在这里，牛的脚上有疼痛的溃疡，这些溃疡感染了居住在泥浆中的细菌，而且非常难以治疗。仅在英国，农业每年的成本就高达6000万英镑。在世界范围内，它每年远远超过10亿英镑。在剑桥大学农场进行的一项小型研究中，我们发现这些液体绷带能很好地粘附在数字皮炎伤口上，没有明显的不良反应，在单次应用一周后促进愈合并克服相关的跛行。我们现在计划在一个大型农场试验中证明，在治疗效果、动物福利和经济方面，我们的液体绷带在全球奶牛场社区采用，用于管理数字皮炎，这是一个令人信服的案例。