2023 Biology of Aging Gordon Research Conference and Gordon Research Seminar

项目摘要 这项申请申请资金支持2023年戈登研究会议(GRC)的生物学 老龄，将于2023年7月2日至7日在西班牙卡斯特尔德费尔斯的Rey Don Jaime Grand酒店举行，戈登 研究研讨会(GRS)，将于2023年7月1日至2日在同一地点举行，紧接在 GRC。这将是自1962年成立以来的第十六届衰老生物学会议。而老年医学和 老年学学会和他们的会议集中在医学、社会和心理方面 老龄化的后果，在最近20年里，关于老龄化的知识呈爆炸式增长 衰老过程的潜在机制。虽然衰老生物学仍然是一个相对较新的领域，但这一GRC 已经成为未发布的数据展示和讨论的主要论坛，导致会议 在那里人们可以看到激动人心的当前科学和该领域的未来方向。这次会议是独一无二的 它的多样性，反映在2023年会议的主题：“生物衰老概念的演变”。老龄化 在过去的几十年里，研究在识别衰老的关键特征方面取得了长足的进步 详细的分子和细胞分辨率。这些进展使人们越来越认识到，衰老是 可塑性的，不仅在细胞水平上或在无脊椎动物中受到干预，而且可能在一系列 脊椎动物，甚至人类。与此同时，技术的快速进步和人口规模的扩大 实验上易于处理的模型生物体促进了从更广泛的角度研究衰老 整个复杂的生物体。这些研究描绘了一幅更加错综复杂的系统性衰老图景，它们 为宿主防御、中枢神经系统、 微生物区系，以及衰老过程。本GRC将重点介绍一些新兴的自上而下的方法 了解衰老，重点是免疫衰老、神经控制和微生物组。 参与的科学家将介绍无脊椎动物模型生物的基础研究，以及高等生物的研究 有机体。适当地，演讲和海报将反映衰老生物学的多样性，范围从 分子研究，以了解衰老如何影响众多细胞和器官系统和生物体。 我们还将听到有关干预衰老的激动人心的工作。会议将包括一个小组讨论。 讨论、辅导午餐和无数的网络机会。我们多方面的方法来满足 本次会议的目标包括：i)主题和方法具有丰富科学多样性的方案；ii)气氛 促进跨学科合作和促进科学交流；iii)指导机会 促进初级调查员与资深常设调查员之间的互动；以及四)支持 参与的个体多样性。

Project Summary This application requests funds to support the 2023 Gordon Research Conference (GRC) on the Biology of Aging, to be held at Rey Don Jaime Grand Hotel in Castelldefels (Spain) on July 2–7, 2023, and the Gordon Research Seminar (GRS), which will be held at the same location on July 1–2, 2023, immediately prior to the GRC. This will be the sixteenth Biology of Aging meeting since its origin in 1962. While geriatrics and gerontology societies and their conferences have focused on the medical, social, and psychological consequences of aging, in the most recent two decades there has been an explosion of knowledge on underlying mechanisms of the aging process. While the biology of aging is still a relatively new field, this GRC has become the premier forum for unpublished data presentation and discussions, resulting in a meeting where one can view exciting current science and see the future directions of the field. This meeting is unique in its diversity, reflected in the theme of the 2023 conference: “Evolving concepts of organismal aging”. Aging research over the past decades has made great strides to identify key hallmarks of aging at an increasingly detailed molecular and cellular resolution. These advances have led to the growing recognition that aging is malleable and subject to interventions not just at the cellular level or in invertebrates but possibly in a range of vertebrates and even humans. At the same time, rapid advances in technology and the expansion of the experimentally tractable model organisms have facilitated the study of aging from an ever-broader perspective of entire complex organisms. These studies paint a much more intricate picture of systemic aging, and they offer unprecedented new insight into interactions between host defense, the central nervous system, microbiota, and the process of aging. This GRC will highlight some of these emerging top-down approaches to understanding aging with a focus on immune aging, neural control, and the microbiome. Participating scientists will present basic studies in invertebrate model organisms, as well as studies in higher organisms. Appropriately, the talks and posters will reflect the diversity of the biology of aging by ranging from molecular studies to understanding how aging impacts numerous cellular and organ systems and organisms. We will also hear exciting work on interventions to modulate aging. The meeting will incorporate a panel discussion, mentoring lunch, and numerous networking opportunities. Our multifaceted approach to meet the objectives of this meeting include: i) A program rich in scientific diversity of topic and approach; ii) An atmosphere to promote interdisciplinary collaborations and stimulate scientific exchange; iii) Mentoring opportunities to promote interactions between junior investigators and senior, established investigators; and iv) Support of individual diversity in participation.