BEHAVIORAL AND PHYCHOSOCIAL FACTORS IN BREAST CANCER

乳腺癌是最常见的癌症， 美国女性癌症死亡的原因。虽然遗传， 激素，生物和生殖风险因素很重要，因为许多 因为75%的新病例发生在没有已知风险因素的妇女中。可用 数据表明，行为和心理社会因素可能在 乳腺癌的病因和发病机制。缺乏精心设计的 基于人群的研究排除了关于这些的确切结论。 然而，协会。该提案试图利用近30个国家的数据， 从阿拉米达县研究中进行了多年的随访， 对加利福尼亚州阿拉米达县的9，202名成年人（4，994名女性）进行了前瞻性研究， 确定可能在以下方面重要的行为和心理社会因素： 乳腺癌的发生和发展。拟议分析 特别关注身体活动，酒精消费， 社会孤立，社交网络，抑郁，满意度，生活事件， 和个人对乳腺癌风险的不确定性。阿拉米达县研究 收集了大量的行为、社会、心理 和社会人口学变量的大样本县居民， 1965年、1974年、1983年和1994年。超过110，000人-年的暴露量 目前，女性参与者。与CA肿瘤的联系 登记处和SEER登记处使我们能够识别事故案例 乳腺癌的分期，组织学， 治疗。这个丰富的数据集，广泛的可用信息， 与已建立的肿瘤登记处的联系提供了独特的机会， 解决有关具体的 行为和心理社会因素以及乳腺癌风险增加。 这些分析的结果将有助于阐明潜在的病因学影响 这些重要的特征，并可能有助于发展 新的和更有效的干预措施，以防止发病率和 乳腺癌的进展。

Breast cancer is the most frequently diagnosed cancer and second leading cause of cancer death among women in the United States. While genetic, hormonal, biologic, and reproductive risk factors are important, as many as 75% of new cases occur in women with no known risk factors. Available data suggest that behavioral and psychosocial factors may play a role in breast cancer etiology and pathogenesis. A lack of well-designed population-based studies precludes firm conclusions regarding these associations, however. This proposal seek to utilize data from nearly 30 years of follow-up from the Alameda County Study, a population-based, prospective study of 9,202 adults (4,994 women) in Alameda County, CA, to identify behavioral and psychosocial factors that may be important in the development and progression of breast cancer. Proposed analyses specifically focus on the roles of physical activity, alcohol consumption, social isolation, social networks, depression, satisfaction, life events, and personal uncertainty in breast cancer risk. The Alameda County Study has collected a broad range of data on behavioral, social, psychological, and sociodemographic variables on a large sample of county residents in 1965, 1974, 1983, and 1994. Over 110,000 person-years of exposure currently are available for female participants. Linkage to the CA Tumor registry and the SEER Registry has enabled us to identify incident cases of breast cancer, with accompanying details on staging, histology, and treatments. This rich dataset, breadth of available information, and linkage to an established tumor registry present a unique opportunity to address important questions regarding associations between specific behavioral and psychosocial factors and increased risk of breast cancer. Results of these analyses will help clarify the potential etiologic impact of these important characteristics and may contribute to the development of new and more effective interventions for preventing the incidence and progression of breast cancer.