Investigator Development Core

项目摘要/总结-研究者发展核心 迫切需要支持早期研究人员（ESI）研究解决方案，以充分记录 心血管疾病（CVD）和相关慢性疾病（RCC）的差异， 黑人、土著和有色人种（BIPOC）。这项工作需要直接 受影响最严重的群体的参与，这些群体在科学和医学领域的代表性历来不足 （URSM）;不幸的是，URSM调查人员往往缺乏机构资源和结构支持， 成功的关键。为了满足这些需求，拟议的P50的研究者发展（ID）核心 明尼苏达州慢性病减少和公平促进中心（C2 DREAM）有两个主要的 目标：（1）管理一个试点赠款计划，支持和授权获奖者进行高影响力 明尼苏达州BIPOC社区CVD和RCC的研究。(2)培养下一代 调查人员进行多层次、多学科的干预性研究，以解决种族主义和其他 心血管疾病和RCC差异的社会和结构决定因素。这两个目标的基础都是关注 增加科学劳动力的多样性。我们有三个具体目标。目标1：促进发展 并成功开展创新试点项目（5年内至少30个项目）， 一组旨在解决明尼苏达州BIPOC社区CVD和RCC差异的ESI。项目将 针对明尼苏达州和CVD或RCC的一个或多个C2 DREAM优先健康差异人群 差异，与C2 DREAM概念框架保持一致，使用多层次，多领域的方法 与NIMHD框架一致，并包括ESI的指导计划和社区计划 订婚目标2：设计和启动一系列强有力的讲习班、研讨会、建立联系的机会， 研究资源，称为支持和培训的研究成功（星），以促进准备， 生产力和ESIs的进步。目标3：评估ID核心对试点成功的有效性 ESI的项目和职业发展。我们提出创新的、多方面的方法来实现我们的目标。 目标。试点赠款计划包括一个培训选项（试点孵化器密集系列），以提高无资金支持的 应用程序，并保持有前途的调查人员在管道中。我们已经聘请了来自全国各地的>130教师 合作机构作为中心的教师附属机构，他们致力于担任导师， 试点应用审查员。我们将举办参与式研讨会和密集的一对一辅导， 当他们开发同行评审的手稿和未来的赠款提案时， 以及一套支持ESI的资源。ID Core将通过创建严格的基础设施产生影响 旨在促进ESI的成功（包括博士后研究员，ESI和社区研究人员， 该地区其他与C2 DREAM一致的计划），并改善URSM的招聘和保留 研究人员在科学劳动力解决慢性病的差距。

PROJECT ABSTRACT/SUMMARY – Investigator Development Core There is a critical need to support early-stage investigators (ESIs) researching solutions to well-documented disparities in cardiovascular disease (CVD) and related chronic conditions (RCC) that disproportionately burden communities identified as Black, Indigenous and people of color (BIPOC). This work requires direct participation from the groups most affected, who are traditionally underrepresented in science and medicine (URSM); unfortunately, URSM investigators often lack institutional resources and structural supports that are critical for success. To address these needs, the Investigator Development (ID) Core of the proposed P50 Center for Chronic Disease Reduction and Equity promotion Across Minnesota (C2DREAM) has two primary goals: (1) Administer a pilot grant program that supports and empowers awardees to conduct high-impact research on CVD and RCC among BIPOC communities across Minnesota. (2) Prepare the next generation of investigators to conduct multi-level, multi-disciplinary interventional research to address racism and other social and structural determinants of CVD and RCC disparities. Both goals are undergirded by a focus on increasing the diversity of the scientific workforce. We have 3 Specific Aims. Aim 1: Facilitate the development and successful conduct of innovative pilot projects (minimum of 30 projects over 5 years) led by a diverse group of ESIs aimed at addressing CVD and RCC disparities in Minnesota’s BIPOC communities. Projects will target one or more of C2DREAM’s priority health disparities populations in Minnesota and CVD or RCC disparities, be aligned with the C2DREAM conceptual framework, use a multi-level, multi-domain approach consistent with the NIMHD framework, and include a mentoring plan for the ESI and a plan for community engagement. Aim 2: Design and launch a robust series of workshops, seminars, networking opportunities and research resources, called Support and TrAining for Research Success (STARS), to promote preparation, productivity, and advancement of ESIs. Aim 3: Evaluate the effectiveness of the ID Core on success of pilot projects and career development of ESIs. We propose innovative, multifaceted approaches to accomplish our Aims. The pilot grant program includes a training option (Pilot Incubator Intensive series) to improve unfunded applications and keep promising investigators in the pipeline. We have engaged >130 faculty from across our partnering institutions to serve as faculty affiliates for the Center who are committed to serving as mentors and pilot application reviewers. We will conduct participatory workshops and intensive one-on-one coaching with ESIs as they develop peer-reviewed manuscripts and future grant proposals, provide networking opportunities and a suite of resources to support ESIs. The ID Core will have impact by creating a rigorous infrastructure designed to promote success of ESIs (including postdoctoral fellows, ESIs and community researchers from other C2DREAM-aligned programs across the region) and improve recruitment and retention of URSM investigators in the scientific workforce addressing chronic disease disparities.