LUNG CANCER AND EXPOSURE TO CHRYSOTILE AND AMPHIBOLES

围绕着是否 两种不同类型的石棉-- Amphilboles和温石棉-- 有不同的致癌能力。 闪石 假设”认为温石棉不太可能导致肺 癌症和间皮瘤比闪石类更严重。 非生物性 由于缺乏定量数据， 用它来估计单独的剂量-反应曲线， 两种纤维类型 这项提案寻求资金来研究肺癌 和间皮瘤的风险在苏联水泥石棉厂， 这些极好的历史暴露数据是可用的， 这两大类石棉纤维的区别。 的 一个小型研究员，一个职业医生， 流行病学博士生，将进行详细的 历史暴露重建和病例对照研究 肺癌和间皮瘤。 工人队伍 受雇于萨洛尼特水泥石棉制造厂 斯洛文尼亚安霍沃将根据现有的详细工资建造 这份名单可以追溯到20世纪40年代。 案例将是所有事件案例 1964年至1994年， 1959年以后被雇用的人， 1964年至1994年。 它们将被识别为使用 斯洛文尼亚国家癌症登记处的数据， 欧洲最古老的国家登记处。 暴露测量可用于大多数暴露作业 始于1961年。 三种不同的测量方法 使用：测尘计测量颗粒/cm 3， 测量毫克/立方米的方法和膜过滤器 测量纤维/cm 3。 回归分析将用于计算特定操作 这些方法之间的转换系数。 累积寿命 将对接触双萜和温石棉的情况进行估计， 分别用于所有病例和对照。 Logistic回归模型 将被用来估计单独的反射率-共振曲线， 控制吸烟的两种纤维类型（吸烟历史数据 每个工人的医疗记录）。

Considerable controversy surrounds the question of whether the two different ytpes of asbestos -- amphilboles and chrysotile -- have different carcinogenic potencies. The "amphibole hypothesis" holds that chrysotile is less likely to cause lung cancer and mesothelioma than are the amphiboles. The abiolity to clarify this question is limited by a lack of quantitative data with which to estimate separate dose-response curves for the two fiber types. This proposal seeks funds to study lung cancer and mesothelimoma risks in a Sovenian cement asbestos plant in which excellent historical exposure data are available, distinguishing the two broad classes of asbestos fibers. The small Grant Investigator, an occupatinal physician and epidemiology doctoral student, would conduct a detailed historical exposure reconstruction and case control studies of lung cancer and mesothelimoma. The cohort of workers employed in the cement asbestos manufacturing plant of salonit Anhovo, Slovenia will be constructed from existing detailed wage lists which date from the 1940s. Cases will be all incident cases of primary lung cancer or mesothelioma from 1964 to 1994 in those who were hired after 1959 and who worked at least one month between 1964 and 1994. They will be identified using data from the slovenian National Cancer Registry, one of the oldest national registries in Europe. Exposure measurements are available for most exposed jobs begining in 1961. Three different methods of measurement were used: konimeter measuring particles/cm3, a gravimetric method measuring milligrams/m3, and membrane filter measuring fibers/cm3. Regression analyses will be used to calculate operation-specific conversion factors among these methods. Cumulative lifetime exposure to amphilboles and to chrysotile will be estimated sparately for all cases and controls. Logistic regression models will be used to estimate separate exposure-resonse curves for the two fiber types controlling for smoking (smoking history data available on each worker from medical records).