LUNG CANCER AND EXPOSURE TO CHRYSOTILE AND AMPHIBOLES

围绕这一问题存在着相当大的争议 两种不同类型的石棉--双石棉和温石棉-- 具有不同的致癌能力。“闪石” “假设”认为温石棉不太可能引起肺。 癌症和间皮瘤是比角闪石更重要的。无能为力 要澄清这个问题受到缺乏量化数据的限制。 用它来估计不同的剂量-反应曲线 两种纤维类型。这项提案寻求研究肺癌的资金。 和间皮瘤风险在俄罗斯的一家水泥石棉厂 哪些优秀的历史暴露数据可用， 区分两大类石棉纤维。这个 小格兰特调查员，一名职业医生和 流行病学博士生，会进行详细的 血吸虫病的历史暴露重建和病例对照研究 肺癌和间皮瘤。一群工人 在沙龙特水泥石棉制造厂工作 斯洛文尼亚安霍沃将根据现有的详细工资建造 列出了20世纪40年代的日期。案例将是所有突发事件案例 在1964至1994年间因肺癌或间皮瘤 在1959年后受雇并至少工作了一年的 1964至1994年间的月份。它们将使用以下工具进行识别 来自斯洛文尼亚国家癌症登记中心的数据，该中心是 欧洲最古老的国家登记处。 曝光量测量适用于大多数曝光的工作 始于1961年。三种不同的测量方法 使用的是：测量颗粒/厘米3的千分计，一种重量仪 测量毫克/立方米的方法和膜式过滤器 测量纤维/厘米~3。 回归分析将用于计算特定于操作的 这些方法中的换算系数。累积寿命 将估计接触双泡石和温石棉。 对于所有病例和对照都是稀疏的。Logistic回归模型 将被用来估计单独的曝光-共振曲线 控制吸烟的两种纤维类型(吸烟史数据 可从医疗记录中获得每个工人的信息)。

Considerable controversy surrounds the question of whether the two different ytpes of asbestos -- amphilboles and chrysotile -- have different carcinogenic potencies. The "amphibole hypothesis" holds that chrysotile is less likely to cause lung cancer and mesothelioma than are the amphiboles. The abiolity to clarify this question is limited by a lack of quantitative data with which to estimate separate dose-response curves for the two fiber types. This proposal seeks funds to study lung cancer and mesothelimoma risks in a Sovenian cement asbestos plant in which excellent historical exposure data are available, distinguishing the two broad classes of asbestos fibers. The small Grant Investigator, an occupatinal physician and epidemiology doctoral student, would conduct a detailed historical exposure reconstruction and case control studies of lung cancer and mesothelimoma. The cohort of workers employed in the cement asbestos manufacturing plant of salonit Anhovo, Slovenia will be constructed from existing detailed wage lists which date from the 1940s. Cases will be all incident cases of primary lung cancer or mesothelioma from 1964 to 1994 in those who were hired after 1959 and who worked at least one month between 1964 and 1994. They will be identified using data from the slovenian National Cancer Registry, one of the oldest national registries in Europe. Exposure measurements are available for most exposed jobs begining in 1961. Three different methods of measurement were used: konimeter measuring particles/cm3, a gravimetric method measuring milligrams/m3, and membrane filter measuring fibers/cm3. Regression analyses will be used to calculate operation-specific conversion factors among these methods. Cumulative lifetime exposure to amphilboles and to chrysotile will be estimated sparately for all cases and controls. Logistic regression models will be used to estimate separate exposure-resonse curves for the two fiber types controlling for smoking (smoking history data available on each worker from medical records).