TRYPTOPHAN AND NATIVE AMERICAN ALCOHOLISM

色氨酸和美洲原住民酗酒

• 批准号: 2550236
• 负责人: WALTER R ADAMS
• 金额: $ 1.74万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2550236
• 关键词: Native Americans; alcoholic beverage consumption; alcoholism /alcohol abuse; brain; clinical chemistry; clinical research; dietary aminoacid; dietary constituent; essential aminoacid; gender difference; high performance liquid chromatography; human subject; interview; longitudinal human study; neurotransmitter biosynthesis; nutrient requirement; nutrition disorders; nutrition related tag; questionnaires; statistics /biometry; tryptophan

APPLICANT'S ABSTRACT: Alcoholism is a leading cause of morbidity and mortality among rural Native Americans. Research suggests there is a link between susceptibility for problems associated with alcohol abuse and low brain serotonin levels. A potential contributor to low brain serotonin levels is low dietary intake of the essential amino acid tryptophan, serotonin's natural precursor. Dietary studies report Native American diets are high in carbohydrates and fats and low in quality proteins. Low intake of the micronutrients that convert tryptophan to serotonin are also reported. We hypothesize that Native American populations may be at risk for alcohol-related problems due to inadequate intake of tryptophan or the micronutrients that convert it to serotonin. This pilot study will involve a random sample of 30 adult Native American males and 30 adult Native American females living in Caddo County, Oklahoma. 24-hour dietary recalls will be analyzed to quantitate total protein and micronutrient levels and give qualitative data on tryptophan consumption. The Food Frequency Questionnaire will provide data on long-term dietary practices. The Health Habits and History Questionnaire will provide additional information on dietary behaviors. Blood tryptophan levels will be analyzed using high performance liquid chromatography to assess whether blood tryptophan levels are low relative to national norms. AUDIT will provide information on drinking behavior. DrInC, with special focus on conditions associated with low brain serotonin levels, will provide information on severity of negative consequences. Analysis will be conducted by constructing confidence intervals for nutritional data in the sample and comparing this to national norms. Additionally, case-control comparisons will examine the association between nutritional variables and problem drinking. We predict that low tryptophan intake or deficiency in at least one micronutrient will be found in this Native American population. We further predict that severity of drinking and negative consequences will be greater among those with lower values of tryptophan or the micronutrients necessary for the production of serotonin.

申请人摘要：酒精中毒是发病的主要原因， 农村美洲原住民的死亡率。 研究表明 与酗酒和低血糖相关的问题的易感性之间 大脑血清素水平 一个潜在的贡献者低脑血清素 水平是必需氨基酸色氨酸的饮食摄入量低， 血清素的天然前体 饮食研究报告美洲原住民饮食 碳水化合物和脂肪含量高，优质蛋白质含量低。 摄入量低 将色氨酸转化为血清素的微量营养素也 报道 我们假设美洲原住民可能有 用于治疗由于色氨酸摄入不足或 微量营养素转化为血清素 这项初步研究将随机抽取30名成年美洲土著人， 居住在俄克拉荷马州卡多县的30名成年美洲土著女性。 24-小时的饮食回忆将进行分析，以定量总蛋白质， 微量营养素水平，并给出色氨酸消耗的定性数据。 食物频率问卷将提供长期饮食数据 实践 健康习惯和病史问卷将提供 关于饮食行为的更多信息。 血液色氨酸水平将 使用高效液相色谱法进行分析，以评估是否 血液中色氨酸的水平相对于国家标准来说是低的。 审计将 提供有关饮酒行为的信息。 DrInC，特别关注 与大脑血清素水平低有关的疾病，将提供 关于负面后果严重程度的信息。 将通过构建置信区间进行分析， 样本中的营养数据，并将其与国家标准进行比较。 此外，病例对照比较将检查 营养变量和饮酒问题。 我们预测低色氨酸 摄入或缺乏至少一种微量营养素将被发现， 美洲原住民。 我们进一步预测酗酒的严重程度 而负面影响在那些具有较低价值的人中会更大。 色氨酸或产生血清素所必需的微量营养素。