TRYPTOPHAN AND NATIVE AMERICAN ALCOHOLISM

色氨酸和美洲原住民酗酒

• 批准号: 2876540
• 负责人: WALTER R ADAMS
• 金额: $ 1.3万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2876540
• 关键词: Native Americans; alcoholic beverage consumption; alcoholism /alcohol abuse; brain; clinical chemistry; clinical research; dietary aminoacid; dietary constituent; essential aminoacid; gender difference; high performance liquid chromatography; human subject; interview; longitudinal human study; neurotransmitter biosynthesis; nutrient requirement; nutrition disorders; nutrition related tag; questionnaires; statistics /biometry; tryptophan

APPLICANT'S ABSTRACT: Alcoholism is a leading cause of morbidity and mortality among rural Native Americans. Research suggests there is a link between susceptibility for problems associated with alcohol abuse and low brain serotonin levels. A potential contributor to low brain serotonin levels is low dietary intake of the essential amino acid tryptophan, serotonin's natural precursor. Dietary studies report Native American diets are high in carbohydrates and fats and low in quality proteins. Low intake of the micronutrients that convert tryptophan to serotonin are also reported. We hypothesize that Native American populations may be at risk for alcohol-related problems due to inadequate intake of tryptophan or the micronutrients that convert it to serotonin. This pilot study will involve a random sample of 30 adult Native American males and 30 adult Native American females living in Caddo County, Oklahoma. 24-hour dietary recalls will be analyzed to quantitate total protein and micronutrient levels and give qualitative data on tryptophan consumption. The Food Frequency Questionnaire will provide data on long-term dietary practices. The Health Habits and History Questionnaire will provide additional information on dietary behaviors. Blood tryptophan levels will be analyzed using high performance liquid chromatography to assess whether blood tryptophan levels are low relative to national norms. AUDIT will provide information on drinking behavior. DrInC, with special focus on conditions associated with low brain serotonin levels, will provide information on severity of negative consequences. Analysis will be conducted by constructing confidence intervals for nutritional data in the sample and comparing this to national norms. Additionally, case-control comparisons will examine the association between nutritional variables and problem drinking. We predict that low tryptophan intake or deficiency in at least one micronutrient will be found in this Native American population. We further predict that severity of drinking and negative consequences will be greater among those with lower values of tryptophan or the micronutrients necessary for the production of serotonin.

申请人摘要：酗酒是发病和死亡的主要原因 美国农村原住民的死亡率。 研究表明存在联系 与酒精滥用相关的问题的易感性和低度之间 大脑血清素水平。 大脑血清素水平低的潜在因素 水平是必需氨基酸色氨酸的膳食摄入量低， 血清素的天然前体。 饮食研究报告美洲原住民饮食 碳水化合物和脂肪含量高，优质蛋白质含量低。 摄入量低 将色氨酸转化为血清素的微量营养素也 报道称。 我们假设美洲原住民可能面临危险 由于色氨酸摄入不足或与酒精有关的问题 将其转化为血清素的微量营养素。 这项试点研究将随机抽取 30 名成年美洲原住民样本 居住在俄克拉荷马州卡多县的 30 名成年美国原住民男性和 30 名成年女性。 将分析 24 小时饮食回忆，以定量总蛋白质和 微量营养素水平并提供色氨酸消耗量的定性数据。 食物频率调查问卷将提供有关长期饮食的数据 做法。 健康习惯和病史调查问卷将提供 有关饮食行为的附加信息。 血液色氨酸水平会 使用高效液相色谱进行分析，以评估是否 血液色氨酸水平相对于国家标准较低。 审计将 提供有关饮酒行为​​的信息。 DrInC，特别关注 与大脑血清素水平低相关的情况，将提供 有关负面后果严重程度的信息。 将通过构建置信区间来进行分析 样本中的营养数据并将其与国家标准进行比较。 此外，病例对照比较将检查之间的关联 营养变量和饮酒问题。 我们预测低色氨酸 在此情况下将发现至少一种微量营养素的摄入或缺乏 美国原住民人口。 我们进一步预测饮酒的严重程度 对于那些价值观较低的人来说，负面后果会更大 色氨酸或产生血清素所需的微量营养素。