ETIOLOGIC CANCER RESEARCH IN A POPULATION-BASED COHORT

我们建议对基于人群队列研究进行经济有效的扩展， 社区动脉粥样硬化风险（ARIC）研究，包括 癌症病因学研究。总共有15,000名中年人，黑人 和白人，他们首先在 1987-1989.常见癌症的许多已知或潜在危险因素 在基线检查中仔细测量，生物标本 (sera血浆、血细胞和DNA）。三个后续 为1990-1992年、1993-1995年和1996-1998年的考试提供了经费。 参与者在每次检查时报告癌症发生，并 每年报告所有住院，包括癌症住院。关于 到1992年估计发生了450起癌症，平均随访 四年。 ARIC研究可能会长期持续下去，因此将其扩展到包括 癌症终点的成本效益。为此有五个具体目标 为期三年的项目。首先，我们建议在2001年增加以下信息： 常见癌症（乳腺癌、肺癌、结肠癌和肺癌）的已确定风险因素 前列腺）。第二，我们建议扩大 ARIC的基本系统，用于通过将 2001年和2003年，癌症登记研究的队列标识符，可在 四个源群落中的三个，并通过在2001年收集 至03例癌症相关住院治疗的队列成员。三是 经过培训的护士文摘员将对估计的700份资料进行文摘 在1987年1月至12月间发生的癌症 1994年（平均随访6年以上）。第四，在03年，我们 将检验与1）独立病因学作用相关的特定假设 体内脂肪分布、体重、内源性胰岛素和血脂水平 2）慢性阻塞性肺疾病是否是乳腺癌的一个 与吸烟强度无关肺癌危险标记物。第五、 和更广泛的目标是将癌症确定为ARIC中的可靠终点 未来研究遗传和环境风险因素的群组，以及 他们之间的互动。 拟议的项目利用了一个已经建立的 基于人口的大群体，需要相对较少的支持，但 将为常见癌症的病因学研究做出重要贡献 在这个项目中，甚至更远的时候。

We propose a cost-effective expansion of a population-based cohort study, the Atherosclerosis Risk in Communities (ARIC) Study, to encompass etiologic cancer research. A total of 15,000 middle-aged adults, blacks and whites, sampled from four U.S. communities were first examined in 1987-1989. Many known or potential risk factors for common cancers were carefully measured in the baseline examination, and biologic specimens (sera, plasma, blood cells, and DNA) were stored. Three subsequent examinations have been funded: 1990-1992, 1993-1995, and 1996-1998. Participants have reported cancer occurrence at every examination and have annually reported all hospitalizations, including those for cancer. About 450 cancers are estimated to have occurred by 1992, an average follow-up of four years. The ARIC Study is likely to continue long-term, so expanding it to include cancer endpoints is cost-effective. There are five specific aims for this three-year project. First, we propose in Year 01 to augment information on established risk factors for common cancers (breast, lung, colon, and prostate) by means of a phone interview. Second, we propose to expand ARIC's rudimentary system for finding incident cancer cases by linking, in Years 01 and 03, cohort identifiers to cancer registries, available in three of the four source communities, and by collecting in Years 01 through 03 cancer-related hospitalizations of cohort members. Third, a trained nurse abstractor will abstract information on the estimated 700 incident cancers that will have occurred between January 1987 and December 1994 (an average of follow-up of over six years). Fourth, in Year 03 we will test specific hypotheses related to 1) the independent etiologic role of body fat distribution, body mass, endogenous insulin, and lipid levels in breast cancer, and 2) whether chronic obstructive lung disease is a risk marker for lung cancer independent of smoking intensity. The fifth, and broader, aim is to establish cancer as a reliable endpoint in the ARIC cohort for future studies of genetic and environmental risk factors and their interactions. The proposed project, which takes advantage of an already established large population-based cohort, requires relatively little support and yet will contribute substantially to the etiologic research of common cancers during this project and far beyond it.