SUPERCOMPUTER SIMULATION OF THE MAMMALIAN KIDNEY

哺乳动物肾脏的超级计算机模拟

• 批准号: 2520039
• 负责人: JOHN L STEPHENSON
• 金额: $ 31.38万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2520039
• 关键词: computer simulation; computer system design /evaluation; kidney function; model design /development; supercomputer

DESCRIPTION (Adapted from the applicant's abstract): The overall goal is to synthesize experimental data at the membrane and molecular level into predictive mathematical models of the kidney that are useful in understanding both its normal and diseased function. The general purpose of the proposed research is to develop for the first time a mathematical and computer model that includes a realistic architecture, cellular and paracellular transport of water and solutes, and exchange of solutes and water between plasma and red blood cells. The development builds on simpler models, but requires the parallel processing capabilities of supercomputers.

描述（改编自申请人的摘要）：总体目标 就是在膜和分子水平上综合实验数据 肾脏的预测数学模型可用于 了解其正常和患病功能。将军 拟议研究的目的是首次开发 数学和计算机模型，包括现实的架构， 水和溶质的细胞和细胞旁运输以及交换 血浆和红细胞之间的溶质和水。这 开发建立在更简单的模型上，但需要并行 超级计算机的处理能力。

项目成果

Comparison of central core and radially separated models of renal inner medulla.

肾内髓质中央核心模型和径向分离模型的比较。

• DOI: 10.1152/ajprenal.1995.268.4.f693
• 发表时间: 1995
• 期刊: The American journal of physiology.
• 作者: Jen,JF;Wang,H;Tewarson,RP;Stephenson,JL
• 通讯作者: Stephenson,JL

Effect of vasa recta flow on concentrating ability of models of renal inner medulla.

直肠血管血流对肾内髓质模型浓缩能力的影响。

• DOI: 10.1152/ajprenal.1995.268.4.f698
• 发表时间: 1995
• 期刊: The American journal of physiology.
• 作者: Stephenson,JL;Wang,H;Tewarson,RP
• 通讯作者: Tewarson,RP

Convective uphill transport of NaCl from ascending thin limb of loop of Henle.

氯化钠从亨勒环上升细肢的对流上坡输送。

• DOI: 10.1152/ajprenal.1995.268.4.f680
• 发表时间: 1995
• 期刊: The American journal of physiology.
• 作者: Stephenson,JL;Jen,JF;Wang,H;Tewarson,RP
• 通讯作者: Tewarson,RP