RESEARCH TRAINING IN SIGNAL TRANSDUCTION

信号传导研究培训

• 批准号: 2518844
• 负责人: HORACIO G MURILLO
• 金额: $ 3.14万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-25 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2518844
• 关键词: biological signal transduction; curriculum; health science research; medical education; training

The general area of my research interest lies in signal transduction in the cell and among groups of cells, tissues, and organs. Most responses by cells involve ligands and membrane-bound receptors and/or ligands and intracellular soluble or innermembrane-bound receptors which eventually elicit a cellular response. Our understanding of how and through how many steps each process takes place is advancing at an accelerated pace. However, the number and complexity of cellular processes are far greater than can be deciphered in the near fixture. Some examples of my interest include ion channels and G-protein linked receptors and their signaling cascades; the mechanism of mitogenic signal transmission from extracellular sources to the nucleus; cell cycle regulation and its inherent temporal gene expression and cellular events; and cytokine and immunocellular responses. The rationale of such interests is that they are scientifically and medically relevant to human disease and normal physiology.

我的研究兴趣主要集中在细胞内的信号转导， 细胞之间以及细胞群、组织和器官之间。大多数答复 涉及配体和膜结合受体和/或配体， 细胞内可溶性或内膜结合受体， 引发细胞反应我们对如何以及通过多少 每一个进程都在加速前进。 然而，细胞过程的数量和复杂性要大得多 比在近处的灯具中能破译的要多 我感兴趣的一些例子包括离子通道和G蛋白连接 受体及其信号级联;促有丝分裂信号的机制 细胞外信号向细胞核的传递;细胞周期 调控及其固有的时间基因表达和细胞事件; 以及细胞因子和免疫细胞应答。这样的理由 利益是，它们在科学和医学上与人类有关， 疾病和正常生理。