RESEARCH TRAINING IN SIGNAL TRANSDUCTION

我研究的主要领域是信号转导。 细胞之间的细胞、组织和器官。最多回复 由细胞涉及配体和膜结合受体和/或配体和 细胞内可溶的或内膜结合的受体最终 引发细胞反应。我们对如何以及通过多少人 每一个过程所采取的步骤都在加速推进。 然而，细胞过程的数量和复杂性要大得多。 在不久的将来是无法破译的。 我感兴趣的一些例子包括离子通道和G蛋白连接 受体及其信号级联；促有丝分裂信号的机制 从胞外来源到细胞核的传递；细胞周期 调控及其固有的时间基因表达和细胞事件； 以及细胞因子和免疫细胞反应。这样做的理由是 兴趣在于它们在科学和医学上与人类相关 疾病和正常生理。

The general area of my research interest lies in signal transduction in the cell and among groups of cells, tissues, and organs. Most responses by cells involve ligands and membrane-bound receptors and/or ligands and intracellular soluble or innermembrane-bound receptors which eventually elicit a cellular response. Our understanding of how and through how many steps each process takes place is advancing at an accelerated pace. However, the number and complexity of cellular processes are far greater than can be deciphered in the near fixture. Some examples of my interest include ion channels and G-protein linked receptors and their signaling cascades; the mechanism of mitogenic signal transmission from extracellular sources to the nucleus; cell cycle regulation and its inherent temporal gene expression and cellular events; and cytokine and immunocellular responses. The rationale of such interests is that they are scientifically and medically relevant to human disease and normal physiology.