非裔美国人乳腺癌易感基因的鉴定-猫眼课题宝

非裔美国人乳腺癌易感基因的鉴定

批准号：

2463707

负责人：

M W SMITH

金额：

$0.0万

依托单位：

DIVISION OF BASIC SCIENCES - NCI

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/2463707

关键词：

African American alleles brca gene breast neoplasm /cancer diagnosis breast neoplasms gene frequency gene mutation genetic markers human genetic material tag human population genetics linkage disequilibriums neoplasm /cancer genetics racial /ethnic difference

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中文摘要

翻译

一种新的遗传方法“外加剂连锁不平衡作图”

英文摘要

A new genetic method "Mapping by Admixture Linkage Disequilibrium" (MALD) has been proposed and implemented which provides a population and patient cohort-based approach for disease gene identification (Stephens et al., 1994, Amer. J. Hum. Genet. 55:809-824). The method uses genetic markers which have significant allele frequency differences between racial groups and a patient population with a recent history of admixture. A collection of over 200 markers with a 10-centiMorgan systematic spacing and delta values of 30 percent or greater (the largest difference in frequencies between alleles at a locus) has been developed. A group of African-American patients, whose racial group has a history of admixture, is being collected and will be typed for the set of genetic markers. Like traditional linkage studies, additional markers can be used in a region to confirm a positive result and pinpoint the location of a disease gene.

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