IDENTIFICATION OF BREAST CANCER SUSCEPTIBILITY GENES IN AFRICAN AMERICANS

非裔美国人乳腺癌易感基因的鉴定

• 批准号: 2463707
• 负责人: M W SMITH
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2463707
• 关键词: African American; alleles; brca gene; breast neoplasm /cancer diagnosis; breast neoplasms; gene frequency; gene mutation; genetic markers; human genetic material tag; human population genetics; linkage disequilibriums; neoplasm /cancer genetics; racial /ethnic difference

A new genetic method "Mapping by Admixture Linkage Disequilibrium" (MALD) has been proposed and implemented which provides a population and patient cohort-based approach for disease gene identification (Stephens et al., 1994, Amer. J. Hum. Genet. 55:809-824). The method uses genetic markers which have significant allele frequency differences between racial groups and a patient population with a recent history of admixture. A collection of over 200 markers with a 10-centiMorgan systematic spacing and delta values of 30 percent or greater (the largest difference in frequencies between alleles at a locus) has been developed. A group of African-American patients, whose racial group has a history of admixture, is being collected and will be typed for the set of genetic markers. Like traditional linkage studies, additional markers can be used in a region to confirm a positive result and pinpoint the location of a disease gene.

一种新的遗传方法--“混合连锁不平衡作图” (MALD)已经被提出并实施，它提供了一个种群 和基于患者队列的疾病基因识别方法 (Stephens等人，1994，Amer.J.嗯。吉内。55：809-824)。方法 使用具有显著等位基因频率的遗传标记 种族群体和患有多发性硬化症的患者之间的差异 外加剂的近代史。包含200多个标记的集合，其中 10-centiMorgan系统间距和delta值为30%或 更大(等位基因之间频率的最大差异 Locus)已被开发出来。一群非洲裔美国患者，他们的 种族群体有混血的历史，正在被收集并将 对这组遗传标记进行分类。就像传统的链接 研究中，可以在一个地区使用其他标记来确认 阳性结果并精确定位疾病基因的位置。