PRENATAL ALCOHOL EXPOSURE & NEUROPSYCHOLOGICAL FUNCTION

产前酒精暴露

• 批准号: 2651106
• 负责人: KRISTINE L KAEMINGK
• 金额: $ 10万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-25 至 1999-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2651106
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; embryo /fetus toxicology; fetal alcohol syndrome; functional ability; human subject; memory; middle childhood (6-11); neuropsychological tests; neuropsychology; preschool child (1-5); psychomotor function; space perception

The purpose of this proposal is to take a theoretically based approach to examination of effects of prenatal alcohol exposure on cognitive functioning in youth who exhibit Fetal Alcohol Syndrome (FAS) or Fetal Alcohol Effects (FAE). Performance on measures of frontal lobe function, response inhibition, and measures assessing theoretically differentiable aspects of memory function will be emphasized since recent findings and theories of central nervous system (CNS) function suggest that examination of brain-behavior relationships in these areas may be particularly fruitful. The specific aims are to compare performance of groups of children with FAS or FAE with that of age- and sex- matched control groups on frontal and response inhibition measures, and to compare spatial memory in groups of children with FAS or FAE and age- and sex-matched control groups since recent findings suggest that memory for object location, a possible indicator of hippocampal dysfunction, is impaired in youth with FAS or FAE. It is hypothesized that FAS/FAE groups will exhibit deficits on measures of frontal function, response inhibition, and spatial memory relative to control groups. If significant differences exist, analyses of covariance will be used to examine relationships between frontal and response inhibition meadures, and working memory and visuomotor abilities since these also contribute to performance on frontal and response inhibition tasks. Analyses of coveriance will be employed to determine whether group differences in spatial memory, if detected, remain once nonmotor perceptual abilities and memory for nonspatial incormaiton are taken into account. If theoretically consistent and specific differences can be found between FAS/FAE groups and matched controls, this will provide direction for future research examining brain-behavior relationships and guide research on educational and other interventions.

该提议的目的是采用理论上的 检查产前酒精暴露对影响的方法 表现出胎儿酒精综合征的青年认知功能 （FAS）或胎儿酒精效应（FAE）。 措施的表现 额叶功能，响应抑制和措施 评估理论上可区分的内存功能方面 自最近的发现和中心理论以来将被强调 神经系统（CNS）功能表明检查 这些领域的脑行为关系可能特别是 卓有成效。 具体目的是比较小组的表现 患有FAS或FAE的儿童与年龄和性别匹配的儿童 对照组进行额叶和响应抑制措施，以及 比较FAS或FAE儿童组中的空间记忆 自最近发现以来，年龄和性别匹配的对照组 建议对象位置的内存，可能的指标 海马功能障碍，患有FAS或FAE的年轻人受损。 假设FAS/FAE组会在 额叶功能，响应抑制和空间的度量 相对于对照组的记忆。 如果存在重大差异， 协方差的分析将用于检查关系 在额叶和响应抑制作用之间以及工作 记忆和视觉运动能力，因为这些能力也有助于 额叶和响应抑制任务的性能。 分析 掩护将被用来确定是否 如果检测到空间内存的差异，则一旦无运动 非空间Incormaiton的感知能力和记忆是 考虑到。 如果理论上一致且具体 可以在FAS/FAE组之间找到差异并匹配 控件，这将为将来的研究提供指导 大脑行为关系和指导教育和研究的研究 其他干预措施。