MERCURY THREAD ELECTRODE FOR DETERMINING LEAD IN BLOOD

儿童期铅中毒被称为“全国领先的儿童期 环境疾病“。有毒铅的准确测定 具有成本效益的小剂量儿童血液浓缩 举止是一个相当大的挑战。这份提案描述了一部小说 汞丝电极，保持了汞作为一种 电极材料，并消除了与 生物样品中的测量。这种电池设计将水银 在小直径透析管内，然后可以安装在流动中 用于在线检测的流。这项提议的目的是优化 铅的检出限、精密度和线性关系 通过调查在血液中发现的干扰物质的存在 化学、物理和电化学变量的影响 探测器的响应。将调查样品的制备程序 具有自动采样系统，这将导致便携式仪器。 这台仪器不仅将被用来测定血液中的铅，而且 环境和工业中的铅、其他金属和化合物 样本。该设计还将作为通用探测器运行，用于 难还原物质的高效液相色谱测定方法 物质，如含有更高氧化态的化合物 氮气或硫磺。 拟议的商业应用：数百万儿童处于危险之中 在美国有铅中毒的危险。找到并治疗这些儿童将会 要求对几乎所有的婴儿进行筛查。一些州现在强制要求 这些测量值。简单、准确和负担得起的筛查 该工具将在公共和私营卫生部门找到市场。 在相同的市场以及一些行业，铅和其他重质 水域中的金属是一个持续的环境问题。许多工业企业 流程，例如金属电镀公司，可以从监测中受益 加工中的材料。

Childhood lead poisoning is stated to be "the nation's leading childhood environmental disease". The accurate determination of toxic lead concentrations from small volumes of children's blood in cost effective manner is a considerable challenge. This proposal describes a novel mercury thread electrode that maintains the advantages of mercury as an electrode material and eliminates the problems associated with measurements in biological samples. This cell design places mercury inside a small diameter dialysis tube which can then be mounted in a flow stream for on line detection. The aims of this proposal are to optimize detection limits, precision and linearity for the determination of lead in the presence of interfering substances found in blood by investigating the chemical, physical and electrochemical variables that affect the detector's response. Sample preparation procedures will be investigated with an automated sampling system that will lead to a portable instrument. Not only will this instrument be used for determining lead in blood but also lead, other metals and compounds from environmental and industrial samples. The design will also operate as a general purpose detector for liquid chromatography for the determination of difficult to reduce substances such as compounds containing the higher oxidation states of nitrogen or sulfur. PROPOSED COMMERCIAL APPLICATION: There are millions of children at risk of lead poisoning in the US. Finding and treating these children will require screening virtually all infants. Some states are now mandating these measurements. A simple, accurate and affordable screening instrument would find markets in the public and private health sectors. In the same markets as well as in some industries, lead and other heavy metals in waters are an ongoing environmental concern. Many industrial processes, e.g., metal plating companies, could benefit from monitoring materials in process.