MERCURY THREAD ELECTRODE FOR DETERMINING LEAD IN BLOOD

用于测定血液中铅的汞丝电极

• 批准号: 2444227
• 负责人: CRAIG S BRUNLETT
• 金额: $ 30.51万
• 依托单位: BIOANALYTICAL SYSTEMS, INC. (BASI)
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-05 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2444227
• 关键词: biomedical equipment development; blood chemistry; clinical biomedical equipment; data collection methodology /evaluation; electrochemistry; lead poisoning; mercury; microdialysis; microelectrodes; toxicant screening

Childhood lead poisoning is stated to be "the nation's leading childhood environmental disease". The accurate determination of toxic lead concentrations from small volumes of children's blood in cost effective manner is a considerable challenge. This proposal describes a novel mercury thread electrode that maintains the advantages of mercury as an electrode material and eliminates the problems associated with measurements in biological samples. This cell design places mercury inside a small diameter dialysis tube which can then be mounted in a flow stream for on line detection. The aims of this proposal are to optimize detection limits, precision and linearity for the determination of lead in the presence of interfering substances found in blood by investigating the chemical, physical and electrochemical variables that affect the detector's response. Sample preparation procedures will be investigated with an automated sampling system that will lead to a portable instrument. Not only will this instrument be used for determining lead in blood but also lead, other metals and compounds from environmental and industrial samples. The design will also operate as a general purpose detector for liquid chromatography for the determination of difficult to reduce substances such as compounds containing the higher oxidation states of nitrogen or sulfur. PROPOSED COMMERCIAL APPLICATION: There are millions of children at risk of lead poisoning in the US. Finding and treating these children will require screening virtually all infants. Some states are now mandating these measurements. A simple, accurate and affordable screening instrument would find markets in the public and private health sectors. In the same markets as well as in some industries, lead and other heavy metals in waters are an ongoing environmental concern. Many industrial processes, e.g., metal plating companies, could benefit from monitoring materials in process.

儿童铅中毒被称为"全国最严重的儿童期 环境病”。 有毒铅的准确测定 从小体积的儿童血液中提取浓缩物， 态度是一个相当大的挑战。 这篇文章描述了一部小说。 汞丝电极，保持了汞作为一种 电极材料，并消除了与 生物样品的测量。 这种细胞设计将汞 在小直径的透析管内， 用于在线检测流。 该提案的目的是优化 铅测定的检出限、精密度和线性 通过调查血液中存在的干扰物质， 化学、物理和电化学变量， 探测器的反应。 将研究样品制备程序 自动取样系统，这将导致一个便携式仪器。 该仪器不仅可用于测定血液中的铅含量， 还有铅、环境和工业中的其他金属和化合物 样品 该设计还将作为通用探测器运行， 液相色谱法测定难还原 物质如含有较高氧化态的 氮或硫。 建议的商业应用：有数百万儿童处于危险之中 铅中毒在美国 找到并治疗这些孩子 需要筛查几乎所有的婴儿。 一些州现在要求 这些测量。 简单、准确和负担得起的筛查 该工具将在公共和私营卫生部门找到市场。 在同一市场以及某些行业，铅和其他重金属 沃茨中的金属是一个持续的环境问题。 许多工业 处理，例如，金属电镀公司，可以受益于监测 材料在过程中。