BLOOD CHEMISTRY PROFILES AND ETHANOL DEPENDENCE

血液化学特征和乙醇依赖性

• 批准号: 4687755
• 负责人: E MAJCHROWICZ
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687755
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; blood chemistry; convulsions; detoxification; drug withdrawal; ethanol; high density lipoproteins; low density lipoprotein; very low density lipoprotein

The blood plasma lipoprotein profile in ethanol-treated rats was studied by determining the levels of very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) after a single dose (6 g/kg) of ethanol in ethanol-dependent rats. Three characteristic neurobehavioral groups of rats were distinguished during the ethanol withdrawal period: (1) the dependent intoxicated (prodromal) group (2) the overt withdrawal syndrome group, and (3) the convulsive seizure group. No significant changes in any lipoproteins were found up to 24 hours after the single dose of ethanol. In the ethanol-dependent rats, VLDL decreased, HDL increased, and no significant change in the LDL levels occurred. These data suggest that elevation of HDL in the blood of rats treated with ethanol for 4 days is similar to that found in human alcoholics.

用免疫组织化学方法研究了乙醇处理大鼠的血浆脂蛋白谱。 测定极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL） 脂蛋白（LDL）和高密度脂蛋白（HDL） （6 g/kg）乙醇依赖性大鼠。 三个特征 乙醇灌胃过程中， 停药期：（1）依赖性中毒（前驱）组（2） 显性戒断综合征组;（3）惊厥发作组。 没有 任何脂蛋白的显著变化被发现后长达24小时， 单剂量乙醇。 在酒精依赖大鼠中，VLDL降低，HDL 增加，LDL水平无显著变化。 这些 数据表明，用高密度脂蛋白处理的大鼠血液中HDL的升高 乙醇4天的效果与人类酗酒者相似。