NONINVASIVE ASSAY OF TOTAL HEMOGLOBIN BY KROMOSCOPY

通过色相镜法对总血红蛋白进行无创测定

• 批准号: 2029549
• 负责人: MYRON J BLOCK
• 金额: $ 28.46万
• 依托单位: OPTIX, LP
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1999-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2029549
• 关键词: biomedical equipment development; biotechnology; clinical biomedical equipment; hemoglobin; human subject; infrared radiation; noninvasive diagnosis; plethysmography; serology /serodiagnosis

DESCRIPTION: The objective of this application involves the development of a noninvasive measurement of total hemoglobin/hematocrit. The applicant has developed proprietary technology specifically designed for noninvasive chemical analysis by near-infrared photometry. One aspect of this technology is the development of the methods to minimize the impact of radiation scattering by blood and tissue components. It is anticipated that for noninvasive measurement of total hemoglobin/ hematocrit, where analyte absorption coefficients are relatively high in comparison with scattering coefficients, the use of specialized, proprietary optical configurations will minimize the effect of scattering and is likely to provide more accurate measurements than previously realized. The applicants propose to measure and optimize device precision as a function of the optical parameters in these configurations for a device operating on human subjects at wavelengths that should be suitable for a total hemoglobin measurement.

描述：本申请的目的涉及开发 非侵入性测量总血红蛋白/红细胞压积。 的 申请人开发了专门设计用于 通过近红外光度法进行非侵入性化学分析。 一个方面 这项技术的发展是最大限度地减少 血液和组织成分的辐射散射的影响。 是 预计对于总血红蛋白/ 血细胞比容，其中分析物吸收系数相对较高， 与散射系数的比较，使用专门的， 专有的光学配置将最大限度地减少 散射，并可能提供更准确的测量比 以前实现的。申请人建议测量和优化 在这些装置中，作为光学参数的函数的装置精度 用于在波长为200 nm的波长下对人类对象进行操作的设备的配置 这应该适合于总血红蛋白测量。