TRIPOD LIGANDS FOR ENZYME MODELS

描述：(摘自申请者的摘要)锌对所有人都是必需的 是生命的形式，是人类第二丰富的微量元素 尸体。相应地，锌参与了各种各样的生物 过程，包括碳水化合物、脂肪、蛋白质和核酸 合成、调节和降解。因此，锌是一种 有效增长和发展不可或缺的要素，但也存在不足 导致器官畸形。为了能够完全理解 缺锌的后果，并因此提出可能的补救措施，它 是理解锌的生物无机化学的最基本的。其目的是 这一建议的目的是更全面地定义锌的生物无机化学。 关于一些锌酶，包括碳水化合物 脱水酶、羧基肽酶、热分解酶和肝醇脱氢酶。 具体地说，锌的生物无机化学将通过 研究合成类似物的化学，即简单分子 旨在模仿活性部位的结构和功能 锌酶。合成的类似物更容易受到结构性的影响， 光谱和机理研究，而不是酶本身，所以 对这些系统的确凿调查将使人们有相当大的洞察力 这些酶的作用机制有待确定。结果是 这些研究可以显著地提高我们对 锌的生物无机化学，因此可能有相当大的意义 为治疗由以下原因引起的疾病提供合理依据的重要性 缺锌。

DESCRIPTION: (Adapted from applicant's abstract) Zinc is essential to all forms of life and is the second most abundant trace element in the human body. Correspondingly, zinc participates in a wide variety of biological processes, which include carbohydrate, lipid, protein and nucleic acid synthesis, regulation, and degradation. Zinc is, therefore, an indispensable element for effective growth and development, with deficiency resulting in organ malformations. In order to be able to understand fully the consequences of zinc deficiency, and hence suggest possible remedies, it is most essential to understand the bioinorganic chemistry of zinc. The aim of this proposal is to define more fully the bioinorganic chemistry of zinc with respect to a selection of zinc enzymes, which include carbonic anhydrase, carboxypeptidase, thermolysis and liver alcohol dehydrogenase. Specifically, the bioinorganic chemistry of zinc will be delineated by studying the chemistry of synthetic analogs, i.e. simple molecules that are intended to mimic both the structure and function of the active sites of zinc enzymes. Synthetic analogs are more amenable to structural, spectroscopic, and mechanistic studies than the enzymes themselves, so that definitive investigations of these systems will allow considerable insight into the mechanism of action of the enzymes to be ascertained. The results of these studies could significantly improve our understanding of the bioinorganic chemistry of zinc and consequently could be of considerable importance in providing a rational basis of curing diseases resulting from zinc deficiency.