TRIPOD LIGANDS FOR ENZYME MODELS

描述：（改编自申请人的摘要）锌是必不可少的所有 是生命形式的第二个最丰富的微量元素在人类 身体 相应地，锌参与多种生物学过程， 过程，包括碳水化合物、脂质、蛋白质和核酸 合成、调节和降解。 因此，锌是一种 有效增长和发展不可缺少的元素， 导致器官畸形 为了能够充分理解 锌缺乏的后果，因此建议可能的补救措施，它 是了解锌的生物无机化学的关键。 目的 这一建议的目的是更全面地定义锌的生物无机化学 对于锌酶的选择，包括碳酶， 脱水酶、羧肽酶、苏氨酸和肝醇脱氢酶。 具体来说，锌的生物无机化学将由以下描述： 研究合成类似物的化学，即简单的分子， 旨在模拟活性位点的结构和功能， 锌酶 合成的类似物更适合于结构， 光谱学和机械学的研究，而不是酶本身，所以， 对这些系统的明确研究将使我们有相当深入的了解 酶的作用机制有待确定。 结果 这些研究可以大大提高我们对 锌的生物无机化学，因此可能是相当重要的 为治疗由以下原因引起的疾病提供合理的依据 锌缺乏症

DESCRIPTION: (Adapted from applicant's abstract) Zinc is essential to all forms of life and is the second most abundant trace element in the human body. Correspondingly, zinc participates in a wide variety of biological processes, which include carbohydrate, lipid, protein and nucleic acid synthesis, regulation, and degradation. Zinc is, therefore, an indispensable element for effective growth and development, with deficiency resulting in organ malformations. In order to be able to understand fully the consequences of zinc deficiency, and hence suggest possible remedies, it is most essential to understand the bioinorganic chemistry of zinc. The aim of this proposal is to define more fully the bioinorganic chemistry of zinc with respect to a selection of zinc enzymes, which include carbonic anhydrase, carboxypeptidase, thermolysis and liver alcohol dehydrogenase. Specifically, the bioinorganic chemistry of zinc will be delineated by studying the chemistry of synthetic analogs, i.e. simple molecules that are intended to mimic both the structure and function of the active sites of zinc enzymes. Synthetic analogs are more amenable to structural, spectroscopic, and mechanistic studies than the enzymes themselves, so that definitive investigations of these systems will allow considerable insight into the mechanism of action of the enzymes to be ascertained. The results of these studies could significantly improve our understanding of the bioinorganic chemistry of zinc and consequently could be of considerable importance in providing a rational basis of curing diseases resulting from zinc deficiency.