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GAP JUNCTION ASSEMBLY--MECHANISMS AND REGULATION

GAP JUNCTION ASSEMBLY--MECHANISMS AND REGULATION
间隙连接组件——机制和调节
批准号：
2734704
负责人：
ROSS G JOHNSON
金额：
$26.94万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
项目状态：
已结题
起止时间：
1991-09-30 至 2001-06-30
来源：
https://reporter.nih.gov/project-details/2734704
关键词：
cell cell interaction cell line cell membrane confocal scanning microscopy cyclic AMP electron microscopy electrophysiology freeze etching gap junctions immunofluorescence technique intracellular transport membrane channels membrane proteins posttranslational modifications protein biosynthesis protein kinase C protein structure function protein transport protein tyrosine kinase voltage /patch clamp

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英文摘要
DESCRIPTION: The aim of this application is to characterize the molecular events involved in the assembly of gap junction channels. The proposal is divided into three aims. First, the investigators will characterize the mechanisms of post-translational control of connexin transport to the plasma membrane. Second, they will analyze the regulation of Cx43 hemichannel gating and the lateral migration of hemichannels. Third, they will study the mechanism(s) by which phosphorylation of Cx43 leads to an inhibition of Gj assembly and communication.
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ENHANCED GAP JUNCTION ASSEMBLY CX43 TRAFFICKING
ENHANCED GAP JUNCTION ASSEMBLY CX43 TRAFFICKING
ENHANCED GAP JUNCTION ASSEMBLY CX43 TRAFFICKING
Gap Junction Assembly: Mechanisms and Regulation
  • 批准号：
    6587028
  • 项目类别：
  • 资助金额：
    $29.15万
  • 财政年份：
    1991
  • 负责人：
    ROSS G JOHNSON
  • 依托单位：
    UNIVERSITY OF MINNESOTA
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