课题基金 / 基金详情

GAP JUNCTION ASSEMBLY--MECHANISMS AND REGULATION

GAP JUNCTION ASSEMBLY--MECHANISMS AND REGULATION
间隙连接组件——机制和调节
批准号：
6018849
负责人：
ROSS G JOHNSON
金额：
$21.31万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
项目状态：
已结题
起止时间：
1991-09-30 至 2001-06-30
来源：
https://reporter.nih.gov/project-details/6018849
关键词：
cell cell interaction cell line cell membrane confocal scanning microscopy cyclic AMP electron microscopy electrophysiology freeze etching gap junctions immunofluorescence technique intracellular transport membrane channels membrane proteins posttranslational modifications protein biosynthesis protein kinase C protein structure function protein transport protein tyrosine kinase voltage /patch clamp

项目摘要

项目成果

ROSS G JOHNSON的其他基金

相似基金

相关文献

中文摘要
翻译
描述：此应用程序的目的是表征分子 缝隙连接通道组装过程中涉及的事件。该提案是 分为三个目标。首先，调查人员将描述 缝隙连接蛋白向血浆转运的翻译后调控机制 薄膜。其次，他们将分析Cx43半通道的调节 门控和半通道的侧向迁移。第三，他们将学习 Cx43磷酸化导致细胞凋亡抑制的机制(S) GJ组装和沟通。
英文摘要
DESCRIPTION: The aim of this application is to characterize the molecular events involved in the assembly of gap junction channels. The proposal is divided into three aims. First, the investigators will characterize the mechanisms of post-translational control of connexin transport to the plasma membrane. Second, they will analyze the regulation of Cx43 hemichannel gating and the lateral migration of hemichannels. Third, they will study the mechanism(s) by which phosphorylation of Cx43 leads to an inhibition of Gj assembly and communication.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ENHANCED GAP JUNCTION ASSEMBLY CX43 TRAFFICKING
ENHANCED GAP JUNCTION ASSEMBLY CX43 TRAFFICKING
ENHANCED GAP JUNCTION ASSEMBLY CX43 TRAFFICKING
Gap Junction Assembly: Mechanisms and Regulation
  • 批准号：
    6587028
  • 项目类别：
  • 资助金额：
    $29.15万
  • 财政年份：
    1991
  • 负责人：
    ROSS G JOHNSON
  • 依托单位：
    UNIVERSITY OF MINNESOTA
海外基金