TRANSCRIPTIONAL REG IN CELL GROWTH AND DEVELOPMENT

描述（申请人描述）： 通过转录进行基因调控是所有生物共有的基本过程 生物系统。 转录调控是关键方面的基础 包括细胞增殖，对环境信号的反应， 分化和多细胞生物的发育。 这 申请要求资助夏季FASEB会议， “细胞生长、分化和分化过程中的转录调控” 发展“这次会议的目的是汇集 从事广泛的转录过程研究的研究人员 使用不同的方法和生物系统。 目标是 提供了一个深入了解这一迅速扩大的领域， 在特定领域的实验性和概念性进展， 传播并应用于新的问题。 化管大会各届会议 将讨论集中在关键领域的不同方法， 基因调控研究。 会议旨在提供一个 概述在认识的基本机制的最新进展， 转录激活和抑制，染色质结构，长距离 和表观遗传对基因表达的影响，以及它们与基因表达的关系。 对环境信号、发育和细胞周期反应的生物学 控制 会议将强调以下重要作用： 转录调控在正常分化和发育中的作用 以及异常基因表达参与癌症的方式， 其它疾病 转录和生物调节机制将 在广泛的物种（酵母，蠕虫，苍蝇，哺乳动物）中进行讨论， 从而可以最好地理解相似性和差异性。 的 会议将于1998年7月25日至30日在科罗拉多州斯诺马斯举行。 会议 将包括正式会谈，非正式海报会议，讨论期间， 为与会科学家提供了充分的互动机会。 与会者 将包括主要研究人员，博士后研究员和研究生 学生 会议将提供一个最新的和具有成本效益的 生物学中最基本和最迅速发展的领域之一的概述 并有望为进一步的研究提供策略。

DESCRIPTION (Applicant's Description): Gene regulation through transcription is a fundamental process common to all biological systems. Transcriptional regulation underlies critical aspects of cell behavior including proliferation, response to environmental signals, differentiation, and the development of multicellular organisms. This application requests funding for a summer FASEB conference on "Transcriptional Regulation during Cell Growth, Differentiation, and Development." The intent of this conference is to bring together researchers engaged in studying a broad range of transcriptional processes using different methodologies and biological systems. The goal is to provide an in-depth view of this rapidly expanding field so that experimental and conceptual advances in specific areas can be rapidly disseminated and applied to new problems. Each session of the conference groups together talks that focus on different approaches to key areas of research of gene regulation. The sessions are designed to provide an overview of recent advances in knowledge of fundamental mechanisms of transcriptional activation and repression, chromatin structure, long-range and epigenetic effects on gene expression, and their relationship to the biology of response to environmental signals, development, and cell-cycle control. The conference will underscore the important role that transcriptional regulation plays in normal differentiation and development and the manner in which aberrant gene expression is involved in cancer and other diseases. Transcriptional and biological regulatory mechanisms will be discussed across a wide range of species (yeast, worms, flies, mammals), such that the similarities and differences can best be appreciated. The conference will be held at Snowmass, CO from July 25-30, 1998. The meeting will include formal talks, informal poster sessions, discussion periods, and ample opportunity for interaction among the attending scientists. Attendees will include principal investigators, postdoctoral fellows, and graduate students. The conference will provide an up-to-date and cost-effective overview of one of the most fundamental and rapidly moving fields in biology and is expected to generate stratagems for further research.