Elucidate genetic regulation of GBM differentiation
阐明 GBM 分化的遗传调控
基本信息
- 批准号:10642431
- 负责人:
- 金额:$ 25.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:Acute Promyelocytic LeukemiaAdultBioinformaticsBiologyBrainBrain NeoplasmsCRISPR/Cas technologyCandidate Disease GeneCell Differentiation processCollectionCytotoxic agentDatabasesDevelopmentDiagnosisDifferentiation TherapyDiseaseEffectivenessEncapsulatedGenesGeneticGlioblastomaGoalsHydrogelsIodidesLeadLiposomesMalignant NeoplasmsMalignant neoplasm of brainMolecular TargetNeuronsOperative Surgical ProceduresPatientsPredispositionPrognosisPropertyPublic HealthRNA interference screenRadiation therapyRegimenRegulationResearchResearch Project GrantsResistanceTherapeuticToxic effectTretinoinTumorigenicityUnited StatesValidationWorkcandidate identificationchemotherapeutic agenteffective therapygenome-wideimprovedlead candidatemolecular markernanoparticlenestin proteinnovelnovel strategiespatient derived xenograft modelpharmacologicsingle-cell RNA sequencingstem cell differentiationstem cellssuccesstargeted deliverytemozolomidetherapeutic evaluationtherapeutic target
项目摘要
Glioblastoma (GBM) is the most common and aggressive form of primary brain cancer with extremely poor
prognosis. New approaches for improved treatment of this disease are desperately needed. Accumulating
evidence suggests that the lack of effective treatment for this disease is because the existing regimens cannot
effectively eliminate glioblastoma stem cells (GSCs), the root of GBM development. One promising approach
to eliminating GSCs is to induce GSC differentiation. Unfortunately, the development of differentiation therapy
for GBM has been limited by our poor understanding of the biology of GSC differentiation. In this application,
we propose to characterize genetic regulation of GSC differentiation and validate genes that can be targeted
for effective GBM differentiation therapy. As preliminary work, we identified a group of genes, which potentially
regulate GSC differentiation toward specific lineages through a combination of RNAi screening and single-cell
RNA sequencing approach. In this application, we will characterize lead GSC differentiation regulatory
candidate genes in Aim 1, and to determine the therapeutic potential of selected genes for GSC differentiation
therapy in Aim 2. Success of this project will lead to identification of novel GSC differentiation regulators that
can be potentially targeted for improved treatment of GBM.
胶质母细胞瘤(GBM)是原发性脑癌中最常见、侵袭性最强的一种,预后极差
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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Jiangbing Zhou其他文献
Jiangbing Zhou的其他文献
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{{ truncateString('Jiangbing Zhou', 18)}}的其他基金
Novel grafted terpolymers for targeted delivery of CRISPR/Cas9- mediated precise genome editing to the brain
新型接枝三元聚合物可将 CRISPR/Cas9 介导的精确基因组编辑靶向递送至大脑
- 批准号:
10004184 - 财政年份:2019
- 资助金额:
$ 25.13万 - 项目类别:
Novel grafted terpolymers for targeted delivery of CRISPR/Cas9- mediated precise genome editing to the brain
新型接枝三元聚合物可将 CRISPR/Cas9 介导的精确基因组编辑靶向递送至大脑
- 批准号:
9810805 - 财政年份:2019
- 资助金额:
$ 25.13万 - 项目类别:
Novel grafted terpolymers for targeted delivery of CRISPR/Cas9- mediated precise genome editing to the brain
新型接枝三元聚合物可将 CRISPR/Cas9 介导的精确基因组编辑靶向递送至大脑
- 批准号:
10226862 - 财政年份:2019
- 资助金额:
$ 25.13万 - 项目类别:
Novel grafted terpolymers for targeted delivery of CRISPR/Cas9- mediated precise genome editing to the brain
新型接枝三元聚合物可将 CRISPR/Cas9 介导的精确基因组编辑靶向递送至大脑
- 批准号:
10677473 - 财政年份:2012
- 资助金额:
$ 25.13万 - 项目类别:
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