INTERNEURONAL MICROCIRCUITRY OF THE RAT NEOSTRIATUM
大鼠新纹状体的神经元微循环
基本信息
- 批准号:2688311
- 负责人:
- 金额:$ 7.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-07-01 至 2000-06-30
- 项目状态:已结题
- 来源:
- 关键词:action potentials biocytin brain electrical activity calcium binding protein cell population study corpus striatum electrical potential electron microscopy gamma aminobutyrate immunocytochemistry interneurons laboratory rat light microscopy neural information processing somatostatin stainings voltage /patch clamp
项目摘要
DESCRIPTION (Adapted from applicant's abstract): The basal ganglia are
critically involved in the organization of motor behavior and sensorimotor
integration. Malfunctions of this system in humans contribute to the
pathophysiology of neuropsychiatric disorders such as schizophrenia and
obsessive compulsive disorder, as well as to neurological diseases such as
Huntington's and Parkinson's disease. Understanding the information
processing within this system in mechanistic terms requires the
understanding of the physiological properties and anatomical organization of
the microcircuitry of its constituent nuclei. The neostriatum, the largest
nucleus of the basal ganglia has a central role in controlling the
functioning of the basal ganglia and therefore, an understanding of the
intrinsic operations of this nucleus is critical to understanding
information processing in the basal ganglia. Recently, it has been
increasingly recognized that the quantitatively minor population of
GABAergic interneurons of the neostriatum may play a critical role in the
organization of the population activity of the principal cells. However,
until the recent introduction of visually guided whole cell recording these
neurons were not accessible for physiological investigation. In the
proposed study, this powerful technology will be used in combination with
intracellular staining and light and electron microscopic analysis to
analyze the role of these interneurons in the control of the activity of
their principal postsynaptic targets, the medium spiny neuron. Simultaneous
paired recordings will be obtained from interneurons and medium spiny cells
and the neurons will be stained for further anatomical investigation. The
following specific questions will be addressed. First, what is the nature
of the synaptic interaction between the two major types of inhibitory
inteneurons and the medium spiny neuron? Second, what are the physiological
and anatomical specializations of the inhibitory inputs to the medium spiny
neuron from different types of interneurons? Third, what is the pattern of
connectivity among the populations of interneurons and medium spiny neurons
(i.e. convergence and divergence)? Finally, what are the physiological
properties of electrical coupling between interneurons, a potentially
significant mechanism affecting the population activity of these cells, as
well as, the medium spiny neurons? This data will help in understanding the
contribution of these interneurons to the organization of activity in the
neostriatum.
描述(改编自申请人摘要):基底神经节是
关键参与运动行为和感觉运动的组织
一体化 人体内这一系统的故障有助于
神经精神障碍如精神分裂症的病理生理学,
强迫症,以及神经系统疾病,
亨廷顿舞蹈症和帕金森氏症。 了解信息
在该系统中的机械处理要求
了解的生理特性和解剖组织的
构成原子核的微电路 新纹状体,最大的
基底神经节的核在控制
基底神经节的功能,因此,了解
这个核心的内在运作对于理解
基底神经节的信息处理 近日有
越来越多地认识到,
新纹状体的GABA能中间神经元可能在脑缺血中起关键作用。
组织主要细胞的群体活动。 然而,在这方面,
直到最近引入视觉引导的全细胞记录这些
神经元不能用于生理研究。 在
这项强大的技术将结合使用,
细胞内染色以及光镜和电镜分析,
分析这些中间神经元在控制神经元活动中的作用。
它们的主要突触后靶点,即中型多刺神经元。 同时
将从中间神经元和中等多刺细胞获得成对记录
并将神经元染色以用于进一步的解剖学研究。 的
将讨论以下具体问题。 第一,是什么性质
两种主要的抑制性突触之间的相互作用
中间神经元和中间棘神经元? 第二,什么是生理
和对中棘的抑制性输入的解剖学特化
不同类型的中间神经元? 第三,什么是模式
中间神经元和中型棘神经元群体之间的连接
(i.e.收敛和发散)。 最后,什么是生理
中间神经元之间的电耦合特性,一种潜在的
影响这些细胞群体活性的重要机制,
以及中型多刺神经元 这些数据将有助于了解
这些中间神经元对组织活动的贡献,
新纹状体
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
James M Tepper其他文献
James M Tepper的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('James M Tepper', 18)}}的其他基金
INTERNEURONAL MICROCIRCUITRY OF THE RAT NEOSTRIATUM
大鼠新纹状体的神经元微循环
- 批准号:
2891128 - 财政年份:1998
- 资助金额:
$ 7.08万 - 项目类别:
Functional Striatal Microcircuits in vivo and in vitro
体内和体外功能性纹状体微电路
- 批准号:
9343480 - 财政年份:1997
- 资助金额:
$ 7.08万 - 项目类别:
ANATOMY AND PHYSIOLOGY OF SUBSTANTIA NIGRA AFFERENTS
黑质传入神经的解剖学和生理学
- 批准号:
6351834 - 财政年份:1997
- 资助金额:
$ 7.08万 - 项目类别:
相似海外基金
EVALUATION OF TC 99M MAG3 BIOCYTIN AS HEPATOBILIARY AGENT
TC 99M MAG3 生物细胞素作为肝胆药物的评价
- 批准号:
6161480 - 财政年份:
- 资助金额:
$ 7.08万 - 项目类别:
STRUCTURAL BASIS FOR AUDITORY PROCESSING LATERAL LEMNISCUS; BIOCYTIN; AVIDIN;
听觉处理外侧丘系的结构基础;
- 批准号:
3868510 - 财政年份:
- 资助金额:
$ 7.08万 - 项目类别: