CONFERENCE ON THE NUCLEAR MATRIX

描述：人们越来越意识到 核结构和基因表达的调控。 特别重要的是， 核矩阵到这些过程。 核基质参与了 基因定位和控制复制和转录。 它也是信号传导的靶向和整合位点 基因表达生理调节因子介导的机制 包括类固醇激素和第二信使调节激活剂 途径。 同样重要的是，核基质蛋白反映了独特的 细胞和组织类型，并在分化过程中进行修饰。 特定的核基质蛋白与乳腺、前列腺 结肠癌、膀胱癌和骨癌，在肿瘤发生期间有特征性变化 进展 因此，核基质蛋白质为 癌症和其他潜在疾病的诊断和预后。 这 会议将重点讨论核矩阵快速增长的领域 研究，并将涵盖广泛的主题，如上所述。 在会议上对这项研究的报道很少， 这是对这个话题的广泛兴趣。 它是一个独特 机会，研究人员在这一领域谁跨越广泛的领域 团结在一起，交流最新的信息和概念。 的 1995年4月，召开了第一次关于核矩阵的基石专题讨论会 并得到了许多参加者的好评。许多著名的 与会者认为这是他们参加过的最令人兴奋的会议之一， 曾经参加过。 随着这一领域过去两年的发展， 我们有充分的理由相信，1998年4月的会议将 与前一次一样令人兴奋，甚至可能更有价值， 一个.

DESCRIPTION: There is a growing awareness of interrelationship between nuclear architecture and the regulation of gene expression. Particularly significant is evidence supporting contributions of the nuclear matrix to these processes. The nuclear matrix is involved in gene localization and in the control of replication and transcription. It is also a site for the targeting and integration of signaling mechanisms mediated by physiological regulators of gene expression including steroid hormones and activators of second messenger regulatory pathways. Equally important, nuclear matrix proteins reflect unique cell and tissue types and undergo modifications during differentiation. Specific nuclear matrix proteins are associated with breast, prostate, colon, bladder and bone cancer with characteristic changes during tumor progression. Nuclear matrix proteins, therefore, provide a basis for diagnosis and prognosis of cancer and potentially other diseases. This meeting will focus on the rapidly growing areas of nuclear matrix research and will cover a wide span of topics as summarized above. Coverage of this research in meetings is poorly represented in relationship to the broad range interest in this topic. It is a unique opportunity for researchers in this field who span a wide range of area to bond together and exchange the latest information and concepts. The first keystone Symposium on the Nuclear Matrix was held in April, 1995 and received rave reviews from many who attended it. Many prominent participants rated it one of the most exciting meetings that they have ever attended. With the developments in this field over the past two years we have every reason to believe that the April, 1998 meeting will be just as exciting and likely even more rewarding than the previous one.