FASEB RESEARCH CONFERENCE: NUCLEAR STRUCTURE AND CANCER

描述（由申请人提供）：本申请是为2003年FASEB夏季研究会议“核结构与癌症”的部分资金，该会议将于2003年6月7日至12日在佛蒙特州萨克顿河的佛蒙特学院举行。 该会议由美国实验生物学学会联合会（FASEB）主办。 将举行九次定期平台会议、两次讲习班和两次海报会议。 将鼓励年轻的研究人员从提交的摘要中挑选，在定期的平台和讲习班会议上作简短的发言。 还将有一个特别的“最新发展”会议，与会者将被选中进行简短的会谈。 本次会议将提供一个论坛，以评估基本的监管和临床意义的修改组织的核酸和调节蛋白，控制基因复制和表达的肿瘤细胞核。 肿瘤相关的核形态学变化和调节因子的亚核组织的研究越来越受到重视。 考虑到这一点，有必要召开一次会议，专门研究细胞中间期细胞核的结构和功能特性，这些特性与癌症的发生和发展有关。 这是世界上唯一一次以这一特定主题为重点的重大会议。 核形态和基因复制和表达之间的相关性将被系统地探讨。 将共同努力，批判性地评估核组织、基因组功能和调节之间相互作用的发现。 将考虑从细胞，生物化学，遗传和分子方法的贡献，并将其整合到多学科的方法，以了解基因组组织，功能和癌症之间的联系。 在这样做的过程中，本次会议将解决实验策略和高分辨率的最先进的方法，用于定义癌细胞中与基因复制，表达和调控变化相关的核结构改变。

DESCRIPTION (provided by applicant): This application is for partial funding for the 2003 FASEB Summer Research Conference on "Nuclear Structure and Cancer" to be held June 7-12, 2003 at the Vermont Academy in Saxtons River, Vermont. The conference is under the auspices of the Federation of American Societies for Experimental Biology (FASEB). There will be nine regular platform sessions, two workshops and two poster sessions. Young investigators will be encouraged to give short talks at the regular platform and workshop sessions by selection from the submitted abstracts. There will also be a special "late breaking development" session in which participants will be selected to give short talks. This conference will provide a forum to evaluate the fundamental regulatory and clinical implications of modified organization of nucleic acids and regulatory proteins that control gene replication and expression in nuclei of tumors cells. The study of tumor-related changes in nuclear morphology and the subnuclear organization of regulatory factors is gaining increased attention. With this in mind there is a need for a conference that is dedicated to examining the structural and functional properties of the interphase cell nucleus in cells that are compromised with the onset and progression of cancer. This is the only major meeting in the world that focuses on this specific topic. Correlations between nuclear morphology and gene replication and expression will be systematically explored. There will be a concerted effort to critically evaluate findings that interface between nuclear organization, genomic function and regulation. Consideration will be given to contributions from cellular, biochemical, genetic and molecular approaches and their integration into multidisciplinary approaches for understanding the connections among genomic organization, function and cancer. In so doing this meeting will address experimental strategies and high resolution state-of-the-art methodologies for defining in cancer cells alterations in nuclear architecture related to changes in gene replication, expression and regulation.