CONFERENCE ON TRANSCRIPTIONAL MECHANISMS

转录机制会议

• 批准号: 2708970
• 负责人: Steven J. Triezenberg
• 金额: $ 0.3万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-25 至 1999-02-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2708970
• 关键词: genetic transcription; meeting /conference /symposium; travel

DESCRIPTION (adapted from the investigator's abstract): Advances in the genetic and biochemical dissection of transcriptional mechanisms have been bolstered by biophysical descriptions of the structures and interactions of the proteins and nucleic acids involved. Exciting progress has been made in studies of combinatorial and synergistic regulation by activators and repressors, their effects at various stages of the transcription cycle, and their influence on the role of chromatin in gene regulation. Mechanistic studies are increasingly influenced by consideration of the biological context of transcriptional events. The goal of this meeting is to bring together researchers exploring transcriptional mechanisms in a variety of biological systems using a broad range of experimental approaches. The proposed program integrates contributions from prokaryotic and eukaryotic systems, with experimental strategies including genetics, biochemistry, protein crystallography and cell biology. Session topics include dissection of the components of the transcriptional machinery, the structures and actions of activators and repressors, the sequential stages of transcription, and connections of transcription with cellular structures and signalling. The program includes a larger proportion of female and young scientists than has been represented at other major meetings, and their increased visibility will increase their effectiveness as role models. Further opportunities for broad participation are offered at workshop sessions, with short talks selected from submitted abstracts, and poster sessions.

描述（改编自研究者摘要）： 对转录机制的遗传学和生物化学剖析已经被 通过生物物理学的结构和相互作用的描述， 所涉及的蛋白质和核酸。 取得了令人振奋的进展， 活化剂的组合和协同调节的研究， 阻遏物，它们在转录周期各个阶段的作用，以及 它们对染色质在基因调控中的作用的影响。 机械论 研究越来越多地受到生物学因素的影响， 转录事件的背景。 这次会议的目的是 研究人员一起探索各种转录机制， 使用广泛的实验方法的生物系统。 拟议的计划整合了原核生物和 真核系统，包括遗传学在内的实验策略， 生物化学、蛋白质晶体学和细胞生物学。 会议主题 包括解剖转录机制的组成部分， 激活子和抑制子的结构和作用，顺序阶段 以及转录与细胞结构的联系 和信号。 该方案包括较大比例的女性， 年轻的科学家比其他主要会议的代表， 提高他们的知名度将提高他们作为榜样的效力。 讲习班提供更多广泛参与的机会 会议，从提交的摘要和海报中选出简短的演讲 sessions.