CONFERENCE ON TRANSCRIPTIONAL MECHANISMS

描述(改编自调查人员的摘要)： 对转录机制的遗传和生化剖析已经被 由生物物理描述的结构和相互作用的支持 所涉及的蛋白质和核酸。在以下方面取得了令人振奋的进展 激活剂和激活剂的组合与协同调节研究 抑制子，它们在转录周期不同阶段的作用，以及 它们对染色质在基因调控中的作用的影响。机械论 研究越来越多地受到生物学因素的影响 转录事件的上下文。这次会议的目标是使 研究人员共同探索各种基因的转录机制 使用广泛的实验方法的生物系统。 拟议的计划整合了原核生物和 真核系统，包括遗传学在内的实验策略， 生物化学、蛋白质结晶学和细胞生物学。会话主题 包括对转录机器组件的剖析，即 激活物和抑制物的结构和作用，顺序阶段 转录，以及转录与细胞结构的联系 并发出信号。该计划包括更大比例的女性和 年轻科学家比参加其他主要会议的代表更多，以及 他们更高的知名度将增加他们作为榜样的效力。 研讨会提供了更多广泛参与的机会 会议，简短的演讲从提交的摘要中挑选出来，以及海报 会话。

DESCRIPTION (adapted from the investigator's abstract): Advances in the genetic and biochemical dissection of transcriptional mechanisms have been bolstered by biophysical descriptions of the structures and interactions of the proteins and nucleic acids involved. Exciting progress has been made in studies of combinatorial and synergistic regulation by activators and repressors, their effects at various stages of the transcription cycle, and their influence on the role of chromatin in gene regulation. Mechanistic studies are increasingly influenced by consideration of the biological context of transcriptional events. The goal of this meeting is to bring together researchers exploring transcriptional mechanisms in a variety of biological systems using a broad range of experimental approaches. The proposed program integrates contributions from prokaryotic and eukaryotic systems, with experimental strategies including genetics, biochemistry, protein crystallography and cell biology. Session topics include dissection of the components of the transcriptional machinery, the structures and actions of activators and repressors, the sequential stages of transcription, and connections of transcription with cellular structures and signalling. The program includes a larger proportion of female and young scientists than has been represented at other major meetings, and their increased visibility will increase their effectiveness as role models. Further opportunities for broad participation are offered at workshop sessions, with short talks selected from submitted abstracts, and poster sessions.