NITRIC OXIDE IN STROKE--STRATEGIES FOR NEUROPROTECTION

中风中的一氧化氮——神经保护策略

• 批准号: 2751050
• 负责人: David M. Armstrong
• 金额: $ 0.34万
• 依托单位: ALLEGHENY-SINGER RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-11-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2751050
• 关键词: disease /disorder model; electron spin resonance spectroscopy; enzyme inhibitors; glutamate receptor; glutamates; immunocytochemistry; laboratory rat; neuroprotectants; nitric oxide; nitric oxide synthase; stroke

This application is an extension of a grant that examines some of the molecular events associated with focal brain ischemia. The parent grant hypothesized that there is an alteration of calcium-dependent enzymes and glutamate receptors in ischemic-damaged cortical regions. Using the same stroke model, the FIRCA proposal will examine alterations in nitric oxide concentration, as well as putative activity changes in specific sub-species of nitric-oxide synthase enzymes that may be responsible for the altered NO concentrations.

该应用程序是赠款的扩展，该赠款检查了一些 与局灶性脑缺血有关的分子事件。 父母 授予假设存在钙依赖性的改变 缺血性损伤皮质中的酶和谷氨酸受体 地区。 使用相同的中风模型，FIRCA建议将 检查一氧化氮浓度的改变以及推定 一氧化氮合酶的特定亚种的活性变化 可能导致无浓度改变的酶。