ALL EFFECT ON ION TRANSPORT--AA METABOLITES INTERACTION

所有对离子传输的影响——AA 代谢物相互作用

• 批准号: 2685843
• 负责人: JOHN C MC GIFF
• 金额: $ 2.52万
• 依托单位: NEW YORK MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2685843
• 关键词: angiotensin II; arachidonate; eicosanoids; enzyme linked immunosorbent assay; intermolecular interaction; ion transport; laboratory rabbit; laboratory rat; northern blottings; renal tubule; rubidium; tumor necrosis factor alpha

DESCRIPTION The purpose of this study is to evaluate the interactions of angiotensin II (Ang II) and arachidonic acid (AA) metabolites in the regulation of ion transport in the medullary thick ascending limb (mTAL) in the rat kidney. This study will investigate Ang II-induced changes in ion transport in the mTAL by correlating them with Ang II-induced release of eicosanoids. This study will also investigate the possible role of tumor necrosis factor (TNF) in response to Ang II.

描述 本研究的目的是评价血管紧张素II与血管紧张素受体的相互作用。 (Ang II）和花生四烯酸（AA）代谢产物在调节离子 在大鼠肾脏中的髓质粗升支（mTAL）中的转运。 本研究将探讨血管紧张素II诱导的离子转运的变化， mTAL与Ang II诱导的类花生酸释放相关。 这 研究还将调查肿瘤坏死因子（TNF）的可能作用， 针对Ang II。