GLUTAMATERGIC MECHANISM OF DRUG-CONDITIONED BEHAVIOR

药物调节行为的谷氨酸机制

• 批准号: 2736204
• 负责人: ROBERT L BALSTER
• 金额: $ 1.68万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2736204
• 关键词: NMDA receptors; behavior test; behavioral /social science research tag; behavioral habituation /sensitization; behavioral medicine; brain electronic stimulator; cocaine; conditioning; cooperative study; drug abuse; drug abuse chemotherapy; drug adverse effect; electrodes; histology; implant; inhibitor /antagonist; intravenous administration; laboratory rat; morphine; nucleus accumbens; operant conditionings; psychological reinforcement; reinforcer; self medication; self stimulation

DESCRIPTION The proposed project addresses the ability of competitive N-methyl-D-aspartate (NMDA) receptor antagonists to affect responding conditioned with drugs of abuse (morphine, cocaine). It is proposed to study in rats the influence of site-selective NMDA antagonists on: (1) the drug-conditioned activation of locomotor activity; (2) the facilitation of intracranial self-stimulation induced by conditioned stimuli associated with abused drugs or rewarding electrical stimulation; (3) the responding maintained by conditioned reinforcers using intravenous drug self-administration procedures. The NMDA antagonists are to be administered systemically and also centrally into the nucleus accumbens septi through chronically implanted cannuli. The results will clarify the role of the glutamatergic excitatory system, especially its projections to the nucleus accumbens, in mediating the expression of responses conditioned through exposure to drugs of abuse. Secondarily, considering the role conditioned drug effects may have for relapse to, and maintenance of, drug seeking, the results may also provide important directions for the development of medications for the treatment of drug abuse.

描述 该项目旨在提高竞争力。 N-甲基-D-天冬氨酸（NMDA）受体拮抗剂影响反应 滥用药物（吗啡、可卡因）。 提出要 在大鼠中研究了位点选择性NMDA拮抗剂对以下方面的影响：（1） 药物条件性激活自发活动;（2）促进 条件刺激诱发颅内自我刺激 滥用药物或奖励性电刺激;（3） 由条件反射器使用静脉内药物维持 自我管理程序。 将给予NMDA拮抗剂 全身性地并且也通过中枢进入隔核 长期植入的套管。 研究结果将阐明 谷氨酸能兴奋系统，尤其是其向核的投射 在介导的条件反应的表达，通过 暴露于滥用药物。 其次，考虑到角色的条件 药物作用可能对寻求药物的复发和维持有影响， 研究结果也可能为发展 治疗药物滥用的药物。