GLUTAMATERGIC MECHANISM OF DRUG-CONDITIONED BEHAVIOR

描述 拟议的项目解决了具有竞争力的能力 N-甲基-D-天冬氨酸受体拮抗剂对反应的影响 有滥用药物(吗啡、可卡因)的条件。现建议： 部位选择性NMDA拮抗剂对大鼠的影响：(1) 药物对运动活动的激活；(2)易化 条件性刺激诱发的脑内自我刺激 滥用药物或奖励性电刺激；(3)反应 通过静脉注射药物维持条件增强剂 自我管理程序。NMDA拮抗剂将被注射 系统地，也集中地进入伏隔核至 长期植入Cannuli。调查结果将阐明 谷氨酸能兴奋系统，尤其是其向核内的投射 伏隔在调节条件性反应表达中的作用 接触滥用药物。其次，考虑到角色的局限性 药物效应可能对复发和维持药物寻求， 研究结果也可能为下一步的发展提供重要方向 治疗药物滥用的药物。

DESCRIPTION The proposed project addresses the ability of competitive N-methyl-D-aspartate (NMDA) receptor antagonists to affect responding conditioned with drugs of abuse (morphine, cocaine). It is proposed to study in rats the influence of site-selective NMDA antagonists on: (1) the drug-conditioned activation of locomotor activity; (2) the facilitation of intracranial self-stimulation induced by conditioned stimuli associated with abused drugs or rewarding electrical stimulation; (3) the responding maintained by conditioned reinforcers using intravenous drug self-administration procedures. The NMDA antagonists are to be administered systemically and also centrally into the nucleus accumbens septi through chronically implanted cannuli. The results will clarify the role of the glutamatergic excitatory system, especially its projections to the nucleus accumbens, in mediating the expression of responses conditioned through exposure to drugs of abuse. Secondarily, considering the role conditioned drug effects may have for relapse to, and maintenance of, drug seeking, the results may also provide important directions for the development of medications for the treatment of drug abuse.