NEURAL SUBSTRATES OF AVERSION DURING OPIOID WITHDRAWAL

阿片类药物戒断期间厌恶的神经基础

• 批准号: 2770072
• 负责人: GREGORY Olaf HJELMSTAD
• 金额: $ 2.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2770072
• 关键词: avoidance behavior; behavioral /social science research tag; dopamine antagonists; drug abuse chemotherapy; drug addiction; drug withdrawal; ethology; gamma aminobutyrate; glutamates; laboratory rat; morphine; naloxone; neural transmission; neuropharmacology; nonhuman therapy evaluation; nucleus accumbens; opioid receptor; psychopharmacology

DESCRIPTION: (Applicant's Abstract) The overall goal of this research proposal is to investigate the neural mechanisms underlying the aversiveness of opioid withdrawal. In this project, behavioral experiments will be conducted to study the aversiveness of opioid antagonists micro injected into the nucleus accumbens of morphine dependent rats. Specifically, mu a and kappa selective opioid antagonists will be tested for conditioned place aversion, and the potential interaction between dopamine and this aversion will be tested. Concomitantly, in vitro brain slice techniques will be used to study the effects of opioid on the cellular properties of neurons from the shell of the nucleus accumbens. Furthermore, potential changes in these properties will be studied by preparing slices from morphine dependent rats. The results of these experiments should lead to an increased understanding of the specific neural circuitry involved in opioid withdrawal, which may be helpful in developing treatments for overcoming opioid addiction in humans.

描述：（申请人摘要） 这项研究计划的总体目标是研究神经系统 阿片类药物戒断厌恶的潜在机制。 在这 项目，行为实验将进行研究的厌恶 将阿片类拮抗剂微量注射到吗啡的延髓核中， 依赖的老鼠 具体来说，μ a和kappa选择性阿片类药物拮抗剂 将测试条件性位置厌恶，以及潜在的相互作用， 多巴胺和这种厌恶感之间的联系 同时，体外 脑切片技术将用于研究阿片类药物对脑组织的影响。 来自丘脑核壳的神经元的细胞特性。 此外，这些特性的潜在变化将通过以下方式进行研究： 制备吗啡依赖大鼠的切片。 的结果予以 实验应该会增加对特定神经系统的理解。 参与阿片类药物戒断的回路，这可能有助于发展 用于克服人类阿片类药物成瘾的治疗方法。