GLUTEAL ATTACHMENT TO FEMORAL ALLOGRAFTS IN HIP REVISION

髋关节翻修中臀肌与股骨同种异体移植物的附着

• 批准号: 2769543
• 负责人: Grace Elizabeth Pluhar
• 金额: $ 3.05万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2769543
• 关键词: biomechanics; dogs; femur; hip prosthesis; hip surgery; homologous transplantation; musculoskeletal transplantation; striated muscles; tendons

The goals of this research are to increase the functional use and long- term outcome of patients with total hip replacement and hip revision. This study is important due to the necessity of using whole bone segmental allografts to replace proximal femurs that have become deficient in bone stock secondary to menopause, disuse, multiple revision arthroplasties, or that have tumor infiltration. The problem lies in the fact that functional impairment due to inadequate or failed muscle reattachment to the allograft commonly occurs. The working hypothesis for this investigation is that there are specific long-term time-related changes that occur in functional weight-bearing, densitometry, histology, and mechanical characteristics during the incorporation of the allograft tendon and bone following proximal femoral reconstruction that will allow selection of the optimal technique for this reconstruction. Using a canine model, three methods of gluteal attachment to proximal femoral allografts will be compared: (a) a host tendon to allograft tendon attachment using horizontal mattress sutures, (b)a host bone to allograft bone attachment using a cable grip system, and (3) a host bone bicortical half-shell wrapped around the allograft bone without disruption of the host tendon-bone interface. The prosthesis will be cemented to a frozen allograft and this composite cemented to the distal femur after an excision of the proximal 25% of the femur. The animals will be evaluated bimonthly with radiography, densitometry, and functional weight-bearing and at 9 (24 dogs) and 18 (24 dogs) months with histology and mechanical testing following humane euthanasia.

这项研究的目标是增加功能用途和长期的 全髋关节置换和髋关节翻修术患者的远期结局。 由于使用全骨的必要性，本研究具有重要意义。 节段性同种异体骨移植取代已成为 更年期继发的骨量不足，停用，多次翻修 关节成形术，或有肿瘤浸润者。问题出在 由于肌肉不足或衰竭而导致的功能障碍的事实 再附着到同种异体移植物上的情况很常见。的工作假说 这一调查是与特定的长期时间相关的 在功能承重、密度测定、组织学、 以及同种异体移植物植入过程中的力学特性 股骨近端重建后的肌腱和骨骼将允许 为这一重建选择最佳技术。使用 犬模型：三种臀部附着于股骨近端方法 将比较同种异体肌腱：(A)宿主肌腱与同种异体肌腱 使用水平床垫缝合附着，(B)宿主骨与同种异体骨移植 使用电缆夹持系统的骨连接，以及(3)宿主骨双皮质 半壳包裹在同种异体骨周围而不破坏 主肌腱-骨界面。假体将被粘合到冰冻的 同种异体骨移植和这种复合材料粘连到股骨远端 切除股骨近端25%的部分。将对这些动物进行评估 带射线照相、密度测量和功能承重的双月刊 在9个月(24只狗)和18个月(24只狗)时进行组织学和机械学检查 人道安乐死后的测试。

项目成果

Gluteal muscle attachment during proximal femoral reconstruction in a canine model.

犬模型近端股骨重建期间的臀肌附着。

• DOI: 10.1002/jor.20283
• 发表时间: 2007
• 期刊: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
• 作者: Pluhar,GElizabeth;Manley,PaulA;Heiner,JohnP;VanderbyJr,Ray;Markel,MarkD
• 通讯作者: Markel,MarkD