Is the gut important in multiple joint osteoarthritis? A multimodal investigation in humans and pet dogs
肠道在多关节骨关节炎中重要吗?
基本信息
- 批准号:10859955
- 负责人:
- 金额:$ 54.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-07 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAdministrative SupplementAgeAnalgesicsAreaArthralgiaAttentionAutomobile DrivingBiologicalBiological MarkersBiological SciencesBreedingCCL2 geneCanis familiarisCartilageCessation of lifeClinicalCollagenComplementComplement component C1rComplexDataData AnalysesData SetDegenerative polyarthritisDevelopmentDimensionsDiseaseEnrollmentEthnic OriginEtiologyGenerationsGoalsHumanHyperalgesiaIL6 geneIndividualInterleukin-1 betaIntestinal permeabilityInvestigationJointsKneeKnee OsteoarthritisLeaky GutLipopolysaccharidesMachine LearningMacrophage Inflammatory Protein-1MeasuresMethodsMissionModelingMolecularMusculoskeletal DiseasesMusculoskeletal PainNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesNon-Steroidal Anti-Inflammatory AgentsPainPain MeasurementPain ResearchPain managementParentsPathway interactionsPatient CarePatientsPharmacotherapyPhenotypePopulationProteinsRaceRheumatismRoleSamplingSerumSeveritiesSeverity of illnessSpinal GangliaStrategic PlanningStructureStudy of serumTechniquesTherapeuticVitamin D-Binding ProteinWorkadvanced analyticsanalytical methodanalytical toolburden of illnesschronic painclinical phenotypecohortcomplex dataexperiencegut dysbiosisgut microbiomeindividual variationinnovationinterestlipopolysaccharide-binding proteinmachine learning methodmicrobiomemouse modelmultimodalityneoantigensnovelnovel markernovel therapeuticsopioid overdoseosteoarthritis painparent projectpopulation basedpotential biomarkerradiological imagingresponsesexside effectspecific biomarkerssynergismtherapeutic evaluationtreatment response
项目摘要
PROJECT SUMMARY
The parent project (Is the gut important in multiple joint osteoarthritis? A multimodal investigation in humans
and pet dogs, R01AR080733) integrates serum biomarkers and radiographic measures of the burden of the
disease of OA with measures of intestinal permeability and microbiome assessments in both humans and
dogs. It will significantly advance our understanding of the role of a hitherto ignored driving etiology in MJOA –
altered intestinal permeability – and create a novel transspecies model platform for testing therapeutics. This
proposed supplement effectively synergizes with the parent project by adding a focus on a clinically
critical dimension – pain associated with multi-joint osteoarthritis (MJOA). Pain associated with OA is
what patients care about. This supplement will generate data that will help us better understand the multiple
factors that drive pain and uncover novel therapeutic opportunities. We will expand and enhance our existing
innovative work to include novel biomarkers of pain and pain assays relevant to the pain experience in
humans and in dogs. There are two core features of this integration and enhancement: 1) to extend the
analysis of samples in already being collected to include promising serum biomarkers for musculoskeletal pain
and enhance pain phenotyping in the human cohort; 2) to apply advanced analytical techniques to the entire
data set (parent and supplemental data) allowing us to perform elegant and innovative pain phenotyping in
relation to intestinal permeability, gut microbiome and burden of OA. To advance our understanding of
musculoskeletal pain, we will use cutting-edge machine learning analytical approaches to understand how pain
phenotype(s), microbiome enterotype(s) and biomarker endotype(s) vary together and individually to advance
our understanding of the complex multi-modal and multi-dimensional pain experience of OA patients. This
supplement proposal is not a stand-alone project, rather it enriches the parent project and expands the
opportunities for discovery of potential pain therapeutic strategies. The combined expertise of the two PIs and
teams (OA, musculoskeletal pain, application of machine learning) makes us ideally suited to perform the
proposed work. Integrating the supplement work at this stage is fiscally efficient, and scientifically it will
accelerate the generation of data to support new investigative strategies that will lead to a better
understanding of how to mitigate musculoskeletal pain.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of plasma microbial composition with a leaky gut in obesity-related osteoarthritis: An exploratory study.
- DOI:10.1016/j.ocarto.2022.100317
- 发表时间:2022-12
- 期刊:
- 影响因子:0
- 作者:Arbeeva, Liubov;Azcarate-Peril, M. Andrea;Cui, Yang;Nelson, Amanda E.;Loeser, Richard F.
- 通讯作者:Loeser, Richard F.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Duncan Lascelles其他文献
Duncan Lascelles的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Duncan Lascelles', 18)}}的其他基金
Is the gut important in multiple joint osteoarthritis? A multimodal investigation in humans and pet dogs
肠道在多关节骨关节炎中重要吗?
- 批准号:
10677612 - 财政年份:2022
- 资助金额:
$ 54.95万 - 项目类别:
Evaluation of mechanistic role of artemin/GFRα3 signaling in osteoarthritis pain
artemin/GFRα3 信号在骨关节炎疼痛中的机制作用评估
- 批准号:
10444070 - 财政年份:2022
- 资助金额:
$ 54.95万 - 项目类别:
Evaluation of mechanistic role of artemin/GFRα3 signaling in osteoarthritis pain
artemin/GFRα3 信号在骨关节炎疼痛中的机制作用评估
- 批准号:
10615824 - 财政年份:2022
- 资助金额:
$ 54.95万 - 项目类别:
Is the gut important in multiple joint osteoarthritis? A multimodal investigation in humans and pet dogs
肠道在多关节骨关节炎中重要吗?
- 批准号:
10419121 - 财政年份:2022
- 资助金额:
$ 54.95万 - 项目类别:
相似海外基金
A Longitudinal Qualitative Study of Fentanyl-Stimulant Polysubstance Use Among People Experiencing Homelessness (Administrative supplement)
无家可归者使用芬太尼兴奋剂多物质的纵向定性研究(行政补充)
- 批准号:
10841820 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别:
Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity - Administrative Supplement
质子分泌上皮细胞作为附睾粘膜免疫的关键调节剂 - 行政补充
- 批准号:
10833895 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别:
Administrative Supplement: Life-Space and Activity Digital Markers for Detection of Cognitive Decline in Community-Dwelling Older Adults: The RAMS Study
行政补充:用于检测社区老年人认知衰退的生活空间和活动数字标记:RAMS 研究
- 批准号:
10844667 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别:
StrokeNet Administrative Supplement for the Funding Extension
StrokeNet 资助延期行政补充文件
- 批准号:
10850135 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别:
2023 NINDS Landis Mentorship Award - Administrative Supplement to NS121106 Control of Axon Initial Segment in Epilepsy
2023 年 NINDS 兰迪斯指导奖 - NS121106 癫痫轴突初始段控制的行政补充
- 批准号:
10896844 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别:
Biomarkers of Disease in Alcoholic Hepatitis Administrative Supplement
酒精性肝炎行政补充剂中疾病的生物标志物
- 批准号:
10840220 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别:
Administrative Supplement: Improving Inference of Genetic Architecture and Selection with African Genomes
行政补充:利用非洲基因组改进遗传结构的推断和选择
- 批准号:
10891050 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别:
Power-Up Study Administrative Supplement to Promote Diversity
促进多元化的 Power-Up 研究行政补充
- 批准号:
10711717 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别:
Administrative Supplement for Peer-Delivered and Technology-Assisted Integrated Illness Management and Recovery
同行交付和技术辅助的综合疾病管理和康复的行政补充
- 批准号:
10811292 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别:
Sedentary behavior, physical activity, and 24-hour behavior in pregnancy and offspring health: the Pregnancy 24/7 Offspring Study Administrative Supplement
久坐行为、体力活动和 24 小时行为对怀孕和后代健康的影响:怀孕 24/7 后代研究行政补充
- 批准号:
10893074 - 财政年份:2023
- 资助金额:
$ 54.95万 - 项目类别: