ETIOPATHOGENESIS OF UVEITIS

描述：(改编自申请人的摘要)：葡萄膜炎是一种 在美国是导致失明的主要原因。平台炎是一口井- 葡萄膜炎的定义疾病子集。PARS扁平炎的原因也是如此 与其他形式的葡萄膜炎一样，人们往往不为人知。私家侦探已经确认 外周显著增加的36 kDa蛋白(p-36) 活动期扁平炎患者的血液。最近的结果来自 实验室表明，p-36是一种更大的蛋白质的一部分， 大小约为95 kD(p-95)。蛋白质的鉴定 这可能与部分扁平炎的发病机制有关 它的治疗和可能的治疗方法取得了重大进展。具体目标 这项建议的内容如下： A.PARS中P-36和P-95水平与临床疾病的相关性 普兰氏症。 B.确定P-95的结构。 C.研究P-95的组织分布。 定量评估患者的P-36和P-95水平；血液可能 在监测疾病活动和指导治疗方面都有价值。 国际和平协会希望拟议的研究将允许发现 关于眼部炎症机制的重要信息 以及可能设计出更有效的治疗方法 这种病。

DESCRIPTION: (Adapted from the applicant's abstract): Uveitis is a major cause of blindness in the United States. Pars planitis is a well- defined disease subset of uveitis. The cause of pars planitis, as well as other forms of uveitis, is frequently unknown. The PI has identified a 36 kDa protein (p-36) which is markedly increased in the peripheral blood of patients with active pars planitis. Recent results from the laboratory suggest that p-36 is a part of a larger protein which is approximately 95 kD (p-95) in size. The identification of proteins which may contribute to the pathogenesis of pars planitis would be a major advance toward its treatment and possible cure. The specific aims of this proposal are: A. To correlate levels of p-36 and p-95 with clinical disease in pars planitis. B. To determine the structure of p-95. C. To study the tissue distribution of p-95. Quantitative assessment of p-36 and p-95 levels in patients; blood may be of value in both monitoring disease activity and guiding treatment. The PI hopes that the proposed studies will allow the uncovering of important information concerning the mechanism of ocular inflammation in pars planitis, and possibly, to design more effective treatment for this disease.