EPILEPTIFORM DISCHARGE LATERALITY AND HORMONAL SECRETION

描述(研究人员摘要)：大脑控制生殖 主要通过下丘脑对脑下垂体的调节发挥作用 分泌物(1)。下丘脑中调节和产生 促性腺激素释放激素从 颞缘结构，特别是来自杏仁核(1)。大脑 然而，对下丘脑-垂体-His的影响 很少有系统的临床调查。 颞叶癫痫(TLE)是成人最常见的癫痫形式， 通常起源于或至少涉及到颞缘结构 如杏仁核(1)。内侧颞叶发作性放电常见 产生短暂的荷尔蒙变化(1)。频频发生的 慢性生殖内分泌紊乱--和生殖功能障碍 在癫痫患者中，特别是TLE患者中， 频发或持续性发作间期癫痫样改变的考虑 颞缘活动中断可能会导致慢性改变 下丘脑-垂体-性腺分泌的调节和促进 生殖内分泌紊乱的发展(1)。在中国的观察 女性左侧TLE与多囊卵巢综合征相关 (PCO)和右侧TLE与下丘脑闭经相关 (低促性腺激素减退症，HH)，而且，暗示偏侧化 这种效应中的不对称性(1)。因此，TLE可以作为一个典范 评估颞缘结构在大脑调制中的作用 荷尔蒙分泌和生殖功能，以及 脑功能障碍可能在某些特定的病理生理学中起作用 常见的生殖内分泌疾病，如多囊卵巢 综合征和下丘脑闭经，在TLE中表现过多 但通常被认为起源于初级下丘脑。 本次调查将每10分钟抽血一次，并记录 男性和女性单侧TLE患者连续脑电8小时以上 为了确定血清水平和超重构型 促性腺激素和催乳素的分泌1)在患有 TLE和正常对照组，2)与颞叶偏侧性的关系 脑叶发作间期脑电和3)符合 这些特殊的生殖内分泌疾病的发展 其已知与左侧和右侧TLE相关联。

DESCRIPTION (Investigator's Abstract): The brain controls reproductive function primarily through the hypothalamic regulation of pituitary secretion (1). Regions of the hypothalamus which regulate and produce gonadotropin releasing hormone receive extensive direct connections from temporolimbic structures, especially from the amygdala (1). Cerebral influences on the hypothalamopituitary his, however, have received little systematic clinical inquiry. Temporal lobe epilepsy (TLE), the most common form of epilepsy in adults, generally originates in, or at least involves, temporolimbic structures such as the amygdala (1). Medial temporal lobe ictal discharges commonly produce transient hormonal changes (1). The frequent occurrence of chronic reproductive endocrine disorders-and reproductive dysfunction among men and women with epilepsy, in particular those with TLE, raises the consideration that frequent or persistent interictal epileptiform disruption of temporolimbic activity may lead to chronically altered hypothalamopituitary regulation of gonadal secretion and promote the development of reproductive endocrine disorders (1). The observation in women that left-sided TLE is associated with polycystic ovarian syndrome (PCO) and right-sided TLE is associated with hypothalamic amenorrhea (hypogonadotropic hypogonadism, HH) , moreover, suggests a lateralized asyrnmetry in this effect (1). TLE, therefore, may serve as a model to assess the role of temporolimbic structures in the cerebral modulation of hormonal secretion and reproductive function, as well as the role that cerebral dysfunction may have in the pathophysiology of certain common reproductive endocrine disorders, such as polycystic ovarian syndrome and hypothalamic amenorrhea, which are over represented in TLE but have generally been assumed to be of primary hypothalamic origin. This investigation will sample blood every 10 minutes and record continuous EEG over 8 hours in men and women with unilateral TLE in order to determine if serum levels and ultradian patterns of gonadotropin and prolactin secretion 1) differ between individuals with TLE and normal controls, 2) in relation to the laterality of temporal lobe interictal epileptiform EEG discharges and 3) are consistent with the development of those particular reproductive endocrine disorders that are known to be associated with left and right TLE.