CODING OF BEHAVIORAL SEQUENCES IN THE BASAL GANGLIA

描述(改编自申请人的摘要)：本报告的目标 这个项目是为了了解基底神经节的神经机制 调节一系列行为。基底节的运动障碍， 如帕金森氏症和亨廷顿氏症，与一种 严重丧失组织和执行序列的能力 有动静。此外，基底节的认知障碍 多发性抽动症和肥胖性强迫症表明 顺序控制机制可能是基本的 神经节。 在这个项目中，基底神经节中的单个神经元活动将 与要理解的本能和习得行为序列相关 基底节的序列协调，并识别基本 顺序组织的原则。其他目标是 确定习得性神经元是否有不同的底物 和本能序列，并确定计算性质 基底节中与序列相关的神经元组件。 需要检验的一个关键假设是，基底节区的神经元活动 神经节将与梳理环境中的运动有关 序列，当它们发生在外部时，与这些运动无关 这些序列中。在大鼠体内将记录到单个神经元 刻板印象的顺序理发以及动作部件何时 孤立地或以其他顺序模式制造的。最后，实验 将检验新纹状体神经元通过以下方式调节序列的假设 调节感觉运动反应。在这些实验中，神经元 活动将记录在黑质损伤后，这是 扰乱顺序美容，或通过提供皮肤和味觉刺激 在序列执行期间。

DESCRIPTION (Adapted from applicant's abstract): The goal of this project is to understand the neural mechanisms of the basal ganglia that mediate sequences of behavior. Motor disorders of the basal ganglia, such as Parkinson's and Huntington's disease, are associated with a profound loss of the ability to organize and execute sequences of movement. Furthermore, cognitive disorders of the basal ganglia such as Tourette's syndrome and obesessive compulsive disorder suggest that sequential control mechanisms may be a fundamental property of the basal ganglia. In this project, single neuron activity in the basal ganglia will be related to instinctive and learned behavior sequences to understand basal ganglia coordination of sequences, and to identify basic principles for sequential organization. Additional goals are to determine whether there are different neuronal substrates for learned and instinctive sequences and to determine the computational properties of sequence-related neuronal assemblies in the basal ganglia. A key hypothesis to be tested is that neuronal activity in the basal ganglia will be related to movements within the context of grooming sequences, and not related to these movements when they occur outside of these sequences. Single neurons will be recorded in rats during stereotyped sequential grooming and when components of movements are made in isolation or in other sequential patterns. Lastly, experiments will test the hypothesis that neostriatal neurons mediate sequences by modulating sensorimotor responsiveness. For those experiments, neuronal activity will be recorded after lesions of the substantia nigra, which disrupt sequential grooming, or by presenting cutaneous and taste stimuli during sequence execution.