MULTISITE POTENTIO/AMPEROMETRIC NEURAL SENSOR ARRAY

公司名称：Advanced Sensor Technologies，Inc.建议制定一项 多点神经传感器阵列，由显微阵列组成， 在硅上生长的散布的电位和电流传感器 晶圆采用CMOS技术。 传感器阵列将能够 伴随快速多单位神经电位记录 神经递质的释放、降解和再摄取分析， 伏安传感器技术 我们的第二阶段目标包括将恒电位仪、电流计、 以及直接在传感器基板上的致动器控制器， 基于自愿和非自愿的设备的闭环控制 神经输出 我们的最终目标是一个独立的微型神经网络 可提供自主和随意功能的假肢装置 脑损伤/缺陷、脊髓损伤的患者， 感觉器官缺陷 拟定商业应用： 所提出的多位点电位/电流传感器阵列具有 作为神经假体的传导界面的潜力。 另外，传感器阵列可以用于科学研究中。 研究神经活动的电化学机制。

DESCRIPTION: Advanced Sensor Technologies, Inc. proposes to develop a multi-site neural sensor array, consisting of microscopic arrays of interspersed potentiometric and amperometric sensors grown on silicon wafers using CMOS technology. The sensor array will be capable of multi-unit neural potentiometric recording with concomitant rapid neurotransmitter release, degradation, and re-uptake analysis via voltammetric sensor technology. Our Phase-II goals include incorporation of potentiostat, amperometer, and actuator controllers directly on the sensor substrate to provide closed-loop control of devices based upon voluntary and involuntary neural output. Our ultimate vision is a self-contained miniature neural prosthetic device which can provide autonomic and voluntary functions in persons with brain injuries/defects, spinal cord injuries, and sensory organ deficits. PROPOSED COMMERCIAL APPLICATION: The proposed multisite potentiometric/amperometric sensor array has the potential to serve as the transduction interface for neural prostheses. Additionally, the sensor array may be employed in scientific investigations into the electrochemical mechanisms of neural activity.