Personal Monitor to Detect Exposure to Toxic Agents

描述(申请人摘要)：朝着开发一种自动化、 用于检测人体对环境暴露的反应的微型设备 毒素，先进传感器技术公司建议开发一种微型 一种能够提供差别化血胆碱酯酶分析的装置。这个 设备将提供胆碱酯酶水平的分析(乙酰胆碱酯酶和 丁酰胆碱酯酶)使用从手指扎出的一滴血 取样。该系统将是自动化的，以便它可以被 经过最低限度培训的个人，并将在不到五年的时间内产生结果 几分钟。 拟议的设备将为医疗诊所提供能够进行筛查的单元 并确认暴露于草坪护理人员、作物喷洒人员、运动员和第一 化学制剂、杀虫剂或其他有毒物质的响应者(即EMS人员) 化学制品。已经证明，这些药物和其他药物，特别是 那些有机磷或氨基甲酸酯类化合物抑制胆碱酯酶。 (ChE)人体血液中的活动。这些抑制作用通常会持续长达 健康个体暴露后100天。此外，该设备， 设计类似于家庭怀孕测试，可供父母用于测试 他们的孩子暴露在环境毒素中，包括 水果和蔬菜洗得不够干净。 建议的商业应用：不可用

DESCRIPTION (Applicant's abstract): Toward the goal of developing an automated, miniaturized device to detect the body's reaction to exposure to environmental toxins, Advanced Sensor Technologies, Inc. proposes to develop a miniature device capable of providing differential blood cholinesterase analysis. The device will provide analysis of cholinesterase levels (acetylcholinesterase and butyrylcholinesterase) using a single drop of blood obtained from finger prick sampling. The system will be automated such that it may be utilized by minimally trained individuals, and will provide results in less than five minutes. The proposed device will provide health clinics with units capable of screening and confirming exposure of lawn care worker, crop dusters, athletes, and first responders (i.e. EMS personnel) to chemical agents, pesticides, or other toxic chemicals. It has been demonstrated that these, and other drugs, especially those that are organophosphorous or carbamate based, inhibit cholinesterase (ChE) activity in human blood. These inhibitory effects often persist for up to 100 days in a healthy individual after exposure. Additionally, the device, designed similarly to home pregnancy tests, can be utilized by parents to test their children for exposure to environmental toxins, including pesticides on insufficiently washed fruits and vegetables. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE