The genomic landscape of speciation in hominins and other taxa

古人类和其他类群物种形成的基因组景观

• 批准号: DP190103606
• 负责人: Dr Christian Huber
• 金额: $ 14.48万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-05-22 至 2021-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103606
• 关键词: genomic; landscape; speciation; hominins; other

This project will develop a new analytical framework to build detailed genomic maps of speciation genes across different taxa, to determine whether observed speciation is the result of background selection and demography alone, or whether there are actual barriers to gene flow and introgressed DNA. The model will provide novel insights into the mechanistic basis of speciation, specifically whether a common set of genes or pathways are central to the speciation process. The framework will be developed using the large genomic datasets available across a range of plant and animal species. Applying the model to a modern human population dataset will elucidate the role introgressed DNA from Denisovan and Neanderthals has played in shaping human evolutionary history and may provide novel insights into the genetic basis of disease.

该项目将开发一个新的分析框架，以建立不同类群物种形成基因的详细基因组图谱，以确定观察到的物种形成是否是背景选择和人口统计学的结果，或者是否存在基因流动和渗入DNA的实际障碍。该模型将提供新的见解的机制基础的物种形成，特别是一组共同的基因或途径是否是中央的物种形成过程。该框架将使用一系列植物和动物物种的大型基因组数据集进行开发。将该模型应用于现代人类人口数据集将阐明丹尼索瓦人和尼安德特人的基因渗入DNA在塑造人类进化历史中所起的作用，并可能为疾病的遗传基础提供新的见解。