METABOLIC PREDICTORS AND MARKERS OF CHILDHOOD OBESITY

儿童肥胖的代谢预测因素和标志物

• 批准号: 2673652
• 负责人: SONIA CAPRIO
• 金额: $ 22.84万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2673652
• 关键词: beta adrenergic receptor; biomarker; catecholamines; clinical research; disease /disorder proneness /risk; family genetics; glucose clamp technique; human subject; hyperinsulinism; incretin hormone; insulin sensitivity /resistance; leptin; lipid metabolism; lipolysis; magnetic resonance imaging; middle childhood (6-11); obesity; pancreatic islet function

DESCRIPTION: This project focuses on the identification of early metabolic disturbances implicated in the genesis of juvenile obesity. The investigator propose to determine whether hyperinsulinemia or insulin resistance is the primary defect that is present in "high-risk" preadolescent children of obese parents compared to low risk lean preadolescent children of nonobese parents prior to the development of obesity. The applicant will use a modification of the hyperglycemic clamp to quantify insulin secretion in the two groups and to independently assess the influence of gut factors on the betas cell response to hyperglycemia; and she will attempt to ascertain the relationship between leptin levels and the hyperinsulinemia of juvenile obesity; as well as assess whether defective catecholamine induced stimulation of lipolysis might contribute to further weight gain in obese children. To address these issues the investigator will utilize isotopic infusions and microdialysis techniques. The observed metabolic defects will be related to alterations in fat distribution assessed by MRI. The long-term goal is to generate data that will lead to the development of new strategies for the prevention and treatment of juvenile obesity.

描述：该项目的重点是识别早期代谢 与青少年肥胖症的发生有关的紊乱。 的 研究者建议确定高胰岛素血症或胰岛素 阻力是“高风险”中存在的主要缺陷 肥胖父母的青春期前儿童与低风险瘦 非肥胖父母的青春期前儿童， 肥胖 申请人将使用改良的高血糖钳夹 量化两组的胰岛素分泌，并独立评估 肠道因子对高血糖时β细胞反应的影响; 她将试图确定瘦素水平与 青少年肥胖症的高胰岛素血症;以及评估是否 有缺陷的儿茶酚胺诱导的脂解刺激可能有助于 肥胖儿童的体重进一步增加。 为了解决这些问题， 研究人员将利用同位素输注和微透析技术。 观察到的代谢缺陷将与脂肪的改变有关 通过MRI评估分布。 长期目标是生成 将导致制定新的预防战略， 青少年肥胖症的治疗。