MUSCLE REGENERATION IN DIABETIC ANIMALS

糖尿病动物的肌肉再生

• 批准号: 6239909
• 负责人: JAMES H BAKER
• 金额: $ 4.83万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6239909
• 关键词: atrophy; biopsy; diabetes mellitus; histochemistry /cytochemistry; immobilization of body part; laboratory rat; light microscopy; muscle; muscle transplantation; myofibrils; postoperative complications; regeneration; statistics /biometry

Despite the extensive literature describing the neuropathy associated with diabetes, only limited information describes changes in the associated muscle. The broad long term objective of this research will be to provide details of the consequences of certain traumatic events to muscles of diabetics and the extent and rate of recovery that the muscles undergo. The results of these experiments will provide clinicians with the information necessary to better choose a course of treatment for their diabetic patients. Mature Female Sprague-Dawley rats will be used throughout this study. The rats will be divided into four groups: 1. Normal control animals 2. Experimental streptozotocin-diabetic rats 3. Experimental streptozotocin-diabetic rats treated with insulin 4. Restricted fed controls The soleus and extensor digitorum longus muscles are the muscles to be studied during this project. These muscles respectively represent classic examples of slow and fast contracting muscles. Additionally the effects of transplantation and immobilization of these muscles in the rat are well known. The two specific aims of this project are: 1. Is muscle regeneration compromised following muscle transplantation in diabetic rats and if so to what extent? 2. How much fiber atrophy occurs and how long does it take for the muscle to recover following immobilization of the diabetic limb?

尽管有大量文献描述了与神经病变相关的 对于糖尿病患者，只有有限的信息描述了 相关肌肉 这项研究的长期目标将 提供某些创伤事件后果的细节， 糖尿病患者的肌肉和肌肉恢复的程度和速度， 承受。 这些实验的结果将为临床医生提供 必要的信息，以更好地选择一个疗程， 糖尿病患者。 将使用成熟雌性Sprague-Dawley大鼠 在这项研究中。 将大鼠分为四组： 1. 正常对照动物 2. 实验性链脲佐菌素糖尿病大鼠 3. 胰岛素治疗实验性链脲佐菌素糖尿病大鼠 4. 限制美联储控制 比目鱼肌和趾长伸肌是肌肉， 在这个项目中研究。 这些肌肉分别代表 肌肉收缩快慢的典型例子 另外 这些肌肉在大鼠中的移植和制动作用 是众所周知的。 该项目的两个具体目标是： 1. 肌肉移植后肌肉再生是否受损 在糖尿病大鼠中，如果是，程度如何？ 2. 发生多少纤维萎缩以及需要多长时间 糖尿病肢体制动后肌肉恢复？