CYTOCHROME P4501A1

大多数药物和其他外来生物物质在服用前被广泛代谢 淘汰赛。尽管这可能是一个有益的过程，例如激活 作为其药理活性衍生物的前体药物，新陈代谢也可以 导致病理效应。尽管已知有几种酶系统 参与这项活动的细胞色素P450和黄素 单加氧酶(FMO)被广泛认为是至少在 这一过程的初始步骤。人工智能已经建立了一个活跃的 研究计划，以阐明控制因素的表达 人类细胞色素P1A1基因和主要的FMO。目前的工作重点是 抑制物与细胞色素P4501A1基因的相互作用 它的诱导性。正在探索组织特有的控制机制 兔的Fmo1和Fmo2，人类的Bmo3。可能的多态 人类的FMO3基因也在探索中。人工智能目前有五个 全日制博士生和一名轮流博士生在他的实验室里。学生们 从药理学和癌症生物学研究生课程中招募。 在一个或另一个实验室工作的决定主要是基于 轮换体验。很多时候，学生的论文项目是一个 在轮换过程中完成的工作的延伸。学生们有足够的 有机会参加部门研讨会和参加 杂志俱乐部。在后者中，重点放在关键的 对最近感兴趣的出版物进行评估。实验室里有 鼓励实验室工作人员讨论的定期会议 目前的成果和他们可能遇到的具体问题 实验方法。学生们有机会在 人工智能收到的关于他在各种情况下的评估的论文的审查 编辑委员会。还鼓励学生将他们的作业细分为 国家会议，如果被接受，将为他们提供参加会议的资金。 最后，人工智能建立了一个流程来帮助学生留下来 专注于他们的具体项目，这通常会带来良好的结果 出版记录和及时完成研究生培训。

Most drugs and other xenobiotics are extensively metabolized prior to elimination. Although this can be a beneficial process, e.g. activation of a pro-drug to its pharmacologically active derivative, metabolism can also lead to pathological effects. Although several enzyme systems are known to participate in this activity, the cytochromes P450 and flavin-containing monooxygenases (FMO) are widely recognized as the major players in at least the initial steps of this process. The AI has established an active research program to elucidate factors controlling the expression of the human CYP1A1 gene and the predominant FMO. Current work is focused on the interaction of a repressor with the CYP1A1 gene which appears to modulate its inducibility. Tissue-specific control mechanisms are being explored for FMO1 and 2 in the rabbit and BMO3 in the human. Possible polymorphisms in the human FMO3 gene are also being explored. The AI currently has five full-time and one rotating Ph.D. students in his laboratory. Students are recruited both from the Pharmacology and Cancer Biology graduate programs. The decision to work in one laboratory or another are largely based on the rotation experience. Quite often, the students dissertation project is an extension of work performed during the rotation. Students have ample opportunities to attend departmental seminars and to participate in a journal Club. In the latter, an emphasis is placed on a critical evaluation of recent publications of interest. The laboratory holds regular meting wherein laboratory personnel are encouraged to discuss current results and problems they might be encountering in specific experimental approaches. Students are given the opportunity to help in the review of papers the AI receives for evaluation in his role on various editorial boards. Students are also encouraged to subunit their work to national meetings and if accepted, funds are provided for them to attend. Finally, the AI has established a process to aid the students in remaining focused on their specific projects which usually results in a good publication record and a timely finish to their graduate training.